Trusha Bhatt

Prevalence of <i>ESR1</i> Mutations in Cell-Free DNA and Outcomes in Metastatic Breast Cancer

Sarat Chandarlapaty, David Chen, Wei He et al. · JAMA Oncology · 2016 · 495 citations · Full text

Medicine, Molecular Genetics, Oncology +17

Acquired CDK6 amplification promotes breast cancer resistance to CDK4/6 inhibitors and loss of ER signaling and dependence

Chengcheng Yang, Z Li, Trusha Bhatt et al. · Oncogene · 2016 · 430 citations · Full text

Medicine, Oncology, Pharmacology +16

Correlation between PIK3CA mutations in cell-free DNA and everolimus efficacy in HR+, HER2− advanced breast cancer: results from BOLERO-2

Mary Ellen Moynahan, David Chen, Wei He et al. · British Journal of Cancer · 2017 · 135 citations · Full text

Medicine, Molecular Genetics, Oncology +17

Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer

Christopher G. Mayne, Weiyi Toy, Kathryn E. Carlson et al. · Molecular Cancer Research · 2021 · 13 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Abstract S2-07: cfDNA analysis from BOLERO-2 plasma samples identifies a high rate of ESR1 mutations: Exploratory analysis for prognostic and predictive correlation of mutations reveals different efficacy outcomes of endocrine therapy–based regimens

Sarat Chandarlapaty, Patricia Sung, D Chen et al. · Cancer Research · 2016 · 12 citations

Medicine, Molecular Genetics, Oncology +17