Mariëtte Botha

Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase

Tanya Paquet, Claire Le Manach, Diego González Cabrera et al. · Science Translational Medicine · 2017 · 272 citations · Full text

Medicine, Infectious Diseases, Pharmacology +16

Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination

Janette Reader, Mariëtte Botha, Anjo Theron et al. · Malaria Journal · 2015 · 117 citations · Full text

Pharmacy, Biochemistry, Pharmacology +17

Identification of a Potential Antimalarial Drug Candidate from a Series of 2-Aminopyrazines by Optimization of Aqueous Solubility and Potency across the Parasite Life Cycle

Claire Le Manach, Aloysius T. Nchinda, Tanya Paquet et al. · Journal of Medicinal Chemistry · 2016 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Antimalarial Pyrido[1,2-<i>a</i>]benzimidazoles: Lead Optimization, Parasite Life Cycle Stage Profile, Mechanistic Evaluation, Killing Kinetics, and in Vivo Oral Efficacy in a Mouse Model

Kawaljit Singh, John Okombo, Christel Brunschwig et al. · Journal of Medicinal Chemistry · 2017 · 45 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

A Novel Pyrazolopyridine with in Vivo Activity in <i>Plasmodium berghei</i>- and <i>Plasmodium falciparum</i><i>-</i>Infected Mouse Models from Structure–Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines

Claire Le Manach, Tanya Paquet, Christel Brunschwig et al. · Journal of Medicinal Chemistry · 2015 · 37 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17