Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice

Amanda N. Sacino, Mieu Brooks, M. Albert Thomas, +9

Proceedings of the National Academy of Sciences

NeurogenomicsSynaptic TransmissionNeurological ProgressTransgenic MicePeripheral Nerves +22

Activity-dependent FUS dysregulation disrupts synaptic homeostasis

Chantelle F. Sephton, Amy Tang, Ashwinikumar Kulkarni, +10

Proceedings of the National Academy of Sciences

Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice

Amanda N. Sacino, Mieu Brooks, M. Albert Thomas, +7

Acta Neuropathologica

Widespread PathologyNeurodegenerative DiseasesAmyloidogenic α-Synuclein SeedsExperimental NeuropathologyDegenerative Pathology +8

Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker

Amanda N. Sacino, Mieu Brooks, Alex B. McKinney, +4

Journal of Neuroscience

Brain InjectionSynaptic TransmissionNeurochemical BiomarkersNeuronal Injury MarkerPeripheral Nerves +24

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils

Jacob I. Ayers, Mieu Brooks, Nicola J. Rutherford, +4

Journal of Virology

Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

Amanda N. Sacino, Mieu Brooks, Nicholas H. McGarvey, +6

Acta Neuropathologica Communications

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

Xiaolai Zhou, Alexandra M. Nicholson, Yingxue Ren, +19

Brain

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

Zachary A. Sorrentino, Mieu Brooks, Vincent J. Hudson, +4

Molecular Neurodegeneration

Proteolysis of α‐synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology

Amanda N. Sacino, Mieu Brooks, Paramita Chakrabarty, +4

Journal of Neurochemistry

α-Synuclein Inclusion PathologyMolecular BiologyExtracellular AggregatesNeuroinflammationExperimental Neuropathology +17

Loss of Tmem106b exacerbates <scp>FTLD</scp> pathologies and causes motor deficits in progranulin‐deficient mice

Xiaolai Zhou, Mieu Brooks, Peizhou Jiang, +13

EMBO Reports

Knockout MouseNeurodegenerative DiseasesNeurobiology Of DiseaseSynaptic SignalingMedicine +8