Design, Activity, and 2.8 Å Crystal Structure of a <i>C</i> ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

John W. Erickson, David J. Neidhart, John H. VanDrie, +12

Science

Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.

J. M. A. Lange, Deborah A. Paul, Han G. Huisman, +6

BMJ

ImmunologyActive Hiv InfectionSerum SamplesHiv Core AntibodiesViral Persistence +15

Long-Term Evaluation of HIV Antigen and Antibodies to p24 and gp41 in Patients with Hemophilia

J P Allain, Y. Laurian, Deborah A. Paul, +5

New England Journal of Medicine

Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles

A H Kaplan, Jerome A. Zack, Molly A. Knigge, +4

Journal of Virology

Viral ReplicationEncoded ProteaseImmunologyPathologyAntiviral Drug +17

Structure-based, C2 symmetric inhibitors of HIV protease

Dale J. Kempf, Daniel W. Norbeck, LynnMarie Codacovi, +6

Journal of Medicinal Chemistry

Altmetric Attention ScoreMolecular BiologyPharmacotherapyAntiviral DrugPre-clinical Pharmacology +17

Antigenemia and Antibody Titers to Core and Envelope Antigens in AIDS, AIDS-Related Complex, and Subclinical Human Immunodeficiency Virus Infection

Jaap Goudsmit, Joep M. A. Lange, Deborah A. Paul, +1

The Journal of Infectious Diseases

ImmunohematologyIllinois SearchImmunodeficienciesImmunologyImmunodominance +16

Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease.

Andrew H. Kaplan, Scott F. Michael, Robert S. Wehbie, +7

Proceedings of the National Academy of Sciences

ImmunologyMolecular BiologyViral ProteaseCell CultureAntiviral Drug +16

Risk of AIDS related complex and AIDS in homosexual men with persistent HIV antigenaemia.

F. de Wolf, Jaap Goudsmit, Deborah A. Paul, +5

BMJ

ImmunologyHomosexualityHuman Immunodeficiency VirusSocial SciencesHuman Retrovirus +16

Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease

Dale J. Kempf, Kennan C. Marsh, Deborah A. Paul, +7

Antimicrobial Agents and Chemotherapy

ImmunologyAntiviral DrugHuman Immunodeficiency VirusMedicinal ChemistryHuman Retrovirus +15

Correlation of serum HIV antigen and antibody with clinical status in HIV‐I infected patients

Deborah A. Paul, Lawrence A. Falk, Harold A. Kessler, +4

Journal of Medical Virology

Primary ImmunodeficiencyClinical StatusAutoimmune DiseaseAllergyHuman Retrovirus +13