Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Michael Krauthammer, Yong Kong, Byung Hak Ha, +27

Nature Genetics

Somatic VariantMedicineMelanomaCancer GeneticsMolecular Diagnostics +2

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas

Michael Krauthammer, Yong Kong, Antonella Bacchiocchi, +17

Nature Genetics

Rasopathy GenesMedicineIdentifies Recurrent MutationsPhotocarcinogenesisMelanoma +9

PLX4032, a selective BRAF ^V600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF ^WT melanoma cells

Ruth Halaban, Wengeng Zhang, Antonella Bacchiocchi, +7

Pigment Cell & Melanoma Research

Cancer BiologyMelanoma CellsTumor BiologySignaling PathwayCell Regulation +16

Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells

Ruth Halaban, Elaine Cheng, Yuhua Zhang, +5

Proceedings of the National Academy of Sciences

Genome-wide screen of promoter methylation identifies novel markers in melanoma

Yasuo Koga, Mattia Pelizzola, Elaine Cheng, +7

Genome Research

Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism

Ruth Halaban, Sherri Svedine, Elaine Cheng, +3

Proceedings of the National Academy of Sciences

Abnormal Acidification of Melanoma Cells Induces Tyrosinase Retention in the Early Secretory Pathway

Ruth Halaban, Robin S. Patton, Elaine Cheng, +5

Journal of Biological Chemistry

Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma Cells

Ruth Halaban, Elaine Cheng, Yoel Smicun, +1

The Journal of Experimental Medicine

Proper Folding and Endoplasmic Reticulum to Golgi Transport of Tyrosinase Are Induced by Its Substrates, DOPA and Tyrosine

Ruth Halaban, Elaine Cheng, Sherri Svedine, +2

Journal of Biological Chemistry

Translation Rate of Human Tyrosinase Determines ItsN-Linked Glycosylation Level

Andrea Újvári, Rebecca Aron, Thomas Eisenhaure, +5

Journal of Biological Chemistry