MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

Karthik Mallilankaraman, Patrick J. Doonan, César Cárdenas, +11

Cell

MitophagySignal TransductionMitochondrial FunctionNatural SciencesMolecular Biology +8

Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth

James V. Michael, Jeremy G. T. Wurtzel, Guang Fen Mao, +13

Blood

Mitochondrial Reactive Oxygen Species Mediate Lysophosphatidylcholine-Induced Endothelial Cell Activation

Xinyuan Li, Pu Fang, Yafeng Li, +16

Arteriosclerosis Thrombosis and Vascular Biology

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

Dhanendra Tomar, Zhiwei Dong, Santhanam Shanmughapriya, +32

Cell Reports

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

Santhanam Shanmughapriya, Sudarsan Rajan, Nicholas E. Hoffman, +18

Molecular Cell

BiologyBiochemistryMitochondrial FunctionNatural SciencesMedicine +8

Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms

Jason M. Duran, Catherine A. Makarewich, Thomas E. Sharp, +8

Circulation Research

Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function

Leroy C. Joseph, Dimitra Kokkinaki, Mesele-Christina Valenti, +11

JCI Insight

Heart FailureMitochondrial DysfunctionCardiovascular ToxicityRedox BiologyOxidative Stress +15

SLC25A23 augments mitochondrial Ca²⁺uptake, interacts with MCU, and induces oxidative stress–mediated cell death

Nicholas E. Hoffman, Harish C. Chandramoorthy, Santhanam Shanmughapriya, +10

Molecular Biology of the Cell

MICU1 Motifs Define Mitochondrial Calcium Uniporter Binding and Activity

Nicholas E. Hoffman, Harish C. Chandramoorthy, Santhanam Shamugapriya, +13

Cell Reports

Ca ²⁺ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca ²⁺ uniporter gene <i>MCU</i>

Santhanam Shanmughapriya, Sudarsan Rajan, Nicholas E. Hoffman, +14

Science Signaling