Benzoylalanine-Derived Ketoamides Carrying Vinylbenzyl Amino Residues:  Discovery of Potent Water-Soluble Calpain Inhibitors with Oral Bioavailability

W. Lubisch, Edith Beckenbach, Sabina Bopp, +9

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical ScienceOral BioavailabilityPharmacotherapyExperimental Pharmacology +15

G3139 and Other CpG-Containing Immunostimulatory Phosphorothioate Oligodeoxynucleotides Are Potent Suppressors of the Growth of Human Tumor Xenografts in Nude Mice

Volker Gekeler, Petra Gimmnich, Hans-Peter Hofmann, +13

Oligonucleotides

ImmunologyImmunoeditingCell DeathImmunotherapyCancer Biology +14

Dual or Triple Activation of TLR7, TLR8, and/or TLR9 by Single-Stranded Oligoribonucleotides

Alexandra Forsbach, Ulrike Samulowitz, Kirsten Völp, +10

Nucleic Acid Therapeutics

Innate Immune SystemImmunologyImmune RegulationMolecular BiologyHuman Tlr7- +26

Genome-wide Gene Expression Profiling of Formalin-fixed Paraffin-Embedded Breast Cancer Core Biopsies Using Microarrays

Jan Budczies, Wilko Weichert, Aurelia Noske, +7

Journal of Histochemistry & Cytochemistry

Down-regulation of protein kinase Ceta potentiates the cytotoxic effects of exogenous tumor necrosis factor-related apoptosis-inducing ligand in PC-3 prostate cancer cells.

Jürgen Sonnemann, Volker Gekeler, Antje Sagrauske, +3

PubMed

Chemoprevention StrategyApoptosisCell DeathFactor-related Apoptosis-inducing LigandTumor Biology +16

Knock-Down of IL-1Ra in Obese Mice Decreases Liver Inflammation and Improves Insulin Sensitivity

Niclas Franck, Michael Maris, Sarah Nalbandian, +5

PLoS ONE

ImmunologyReceptor AntagonistFatty Liver DiseaseInsulin SignalingInflammation +15

In Vitro Selected RNA Molecules That Bind to Elongation Factor Tu

Veronika Hornung, Hans-Peter Hofmann, Mathias Sprinzl

Biochemistry

Down-regulation of protein kinase Cη potentiates the cytotoxic effects of exogenous tumor necrosis factor–related apoptosis-inducing ligand in PC-3 prostate cancer cells

Jürgen Sonnemann, Volker Gekeler, Antje Sagrauske, +3

Molecular Cancer Therapeutics

Exogenous Tumor NecrosisPkcη KnockdownApoptosisImmunologyCell Death +15

Molecular alterations after Polo-like kinase 1 mRNA suppression versus pharmacologic inhibition in cancer cells

Mathias Schmidt, Hans-Peter Hofmann, Karl Sanders, +3

Molecular Cancer Therapeutics

ApoptosisCell DeathCell CycleCancer BiologyTumor Biology +16

The Chemical Synthesis of Biochemically Active Oligoribonucleotides Using Dimethylaminomethylene Protected Purine H-Phosphonates

Günther Ott, Lubos̆ Arnold, J. Smrt, +4

Nucleosides and Nucleotides

Bioorganic ChemistryEngineeringMolecular BiologyOrganic ChemistryChemical Biology +14