Hitesh Patel

A quantitative analysis of kinase inhibitor selectivity

Mazen W. Karaman, Sanna Herrgård, Daniel K. Treiber et al. · Nature Biotechnology · 2008 · 2.4K citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

A small molecule–kinase interaction map for clinical kinase inhibitors

Miles A. Fabian, William Biggs, Daniel K. Treiber et al. · Nature Biotechnology · 2005 · 1.9K citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +12

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 644 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14

Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

Todd A. Carter, Lisa Wodicka, Neil P. Shah et al. · Proceedings of the National Academy of Sciences · 2005 · 555 citations · Full text

Medicine, Oncology, Pharmacology +14

Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680

Matthew A. Young, Neil P. Shah, Luke H. Chao et al. · Cancer Research · 2006 · 277 citations

Life Sciences, Molecular Biology, Pharmacology +14