Rachel Cornett

Inhibition of Glutathione S-Transferase ζ and Tyrosine Metabolism by Dichloroacetate: A Potential Unifying Mechanism for Its Altered Biotransformation and Toxicity

Rachel Cornett, Margaret O. James, George N. Henderson et al. · Biochemical and Biophysical Research Communications · 1999 · 74 citations

Biochemistry, Medicine, Altered Biotransformation +11

Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats.

Margaret O. James, Rachel Cornett, Zimeng Yan et al. · PubMed · 1997 · 54 citations

Mm Gsh, Lipid Peroxidation, Mm Dca +18

Potential Increased Risk of Ischemic Heart Disease Mortality With Significant Dose Fractionation in the Canadian Fluoroscopy Cohort Study

Lydia B. Zablotska, Mark P. Little, Rachel Cornett · American Journal of Epidemiology · 2013 · 52 citations · Full text

Epidemiology Of Cancer, Radiation Exposure, Dose Fractionation +16

Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.

Margaret O. James, Zimeng Yan, Rachel Cornett et al. · PubMed · 1998 · 40 citations

Experimental Pharmacology, Oxidative Stress, Dca Metabolism +21

Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents

Chandramohan V. Ammini, José M. Fernández‐Cañón, Albert L. Shroads et al. · Biochemical Pharmacology · 2003 · 29 citations

Molecular Pharmacology, Endocrine Disruptors, Biochemistry +10