A generic static headspace gas chromatography method for determination of residual solvents in drug substance

Chang Cheng, Shaorong Liu, Bradford J. Mueller, +1

Journal of Chromatography A

Solvent ExtractionDrug SubstanceGas ChromatographyMedicineDrug Purity +8

Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats.

Margaret O. James, Rachel Cornett, Zimeng Yan, +2

PubMed

Mm GshLipid PeroxidationMm DcaRedox BiologyLabeled Glyoxylate +16

Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.

Margaret O. James, Zimeng Yan, Rachel Cornett, +6

PubMed

Experimental PharmacologyOxidative StressDca MetabolismUrinary MetabolitesToxicology +19

Determination of dichloroacetate and its metabolites in human plasma by gas chromatography–mass spectrometry

Zimeng Yan, George N. Henderson, Margaret O. James, +1

Journal of Chromatography B Biomedical Sciences and Applications

Gas Chromatography–mass SpectrometryBiochemistryGas ChromatographyMedicineEnvironmental Analytical Chemistry +10

Kinetics and Metabolism of Chloral Hydrate in Children: Identification of Dichloroacetate as a Metabolite

George N. Henderson, Zimeng Yan, Margaret O. James, +2

Biochemical and Biophysical Research Communications

Chloral HydrateBiochemistryPhysiologyToxicologyMetabolism +1

Development and Validation of an HPLC Method for Simultaneous Determination of Ibuprofen and 17 Related Compounds

Zunsheng Han, Liping Lü, Lin Wang, +2

Chromatographia

Hplc MethodGas ChromatographyMedicineAnalytical ChemistryPharmacotherapy +10

Metabolism of para-Aminophenol by Rat Hepatocytes

Zimeng Yan, J. G. Nikelly, Lewis B. Killmer, +1

Drug Metabolism and Disposition

Clinical Pharmacology and Toxicology of Dichloroacetate

Peter W. Stacpoole, George N. Henderson, Zimeng Yan, +1

Environmental Health Perspectives

Determination of chloral hydrate metabolites in human plasma by gas chromatography-mass spectrometry

Zimeng Yan, George N. Henderson, Margaret O. James, +1

Journal of Pharmaceutical and Biomedical Analysis

Gas ChromatographyMedicineBioanalysisMass SpectrometryHuman Plasma +9