Zimeng Yan

A generic static headspace gas chromatography method for determination of residual solvents in drug substance

Chang Cheng, Shaorong Liu, Bradford J. Mueller et al. · Journal of Chromatography A · 2010 · 68 citations

Solvent Extraction, Drug Substance, Gas Chromatography +10

Glutathione-dependent conversion to glyoxylate, a major pathway of dichloroacetate biotransformation in hepatic cytosol from humans and rats, is reduced in dichloroacetate-treated rats.

Margaret O. James, Rachel Cornett, Zimeng Yan et al. · PubMed · 1997 · 54 citations

Mm Gsh, Lipid Peroxidation, Mm Dca +18

Pharmacokinetics and metabolism of [14C]dichloroacetate in male Sprague-Dawley rats. Identification of glycine conjugates, including hippurate, as urinary metabolites of dichloroacetate.

Margaret O. James, Zimeng Yan, Rachel Cornett et al. · PubMed · 1998 · 40 citations

Experimental Pharmacology, Oxidative Stress, Dca Metabolism +21

Determination of dichloroacetate and its metabolites in human plasma by gas chromatography–mass spectrometry

Zimeng Yan, George N. Henderson, Margaret O. James et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1997 · 31 citations

Gas Chromatography–mass Spectrometry, Biochemistry, Gas Chromatography +12

Kinetics and Metabolism of Chloral Hydrate in Children: Identification of Dichloroacetate as a Metabolite

George N. Henderson, Zimeng Yan, Margaret O. James et al. · Biochemical and Biophysical Research Communications · 1997 · 27 citations

Chloral Hydrate, Biochemistry, Physiology +3