The IRP1-HIF-2α Axis Coordinates Iron and Oxygen Sensing with Erythropoiesis and Iron Absorption

Sheila A. Anderson, Christopher P. Nizzi, Yuan-I Chang, +10

Cell Metabolism

Iron DeficiencyPeriodic Surface StructuresBiochemistryHeme HomeostasisIron Metabolism +10

<i>Gata2</i> cis-element is required for hematopoietic stem cell generation in the mammalian embryo

Xin Gao, Kirby D. Johnson, Yuan-I Chang, +4

The Journal of Experimental Medicine

GeneticsStem Cell BiologyEmbryologyStem Cell MobilizationHematology +17

Structure and function of a custom anticancer peptide, CB1a

Jiun-Ming Wu, Pey-Shynan Jan, Huichen Yu, +5

Peptides

Medicinal ChemistryMedicinePeptide LibraryPharmacologyCustom Anticancer Peptide +1

Cis-regulatory mechanisms governing stem and progenitor cell transitions

Kirby D. Johnson, Guangyao Kong, Xin Gao, +8

Science Advances

Progenitor CellsMixed-phenotype Acute LeukemiaGeneticsCis-regulatory MechanismsEpigenetics +17

NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions

Jinyong Wang, Guangyao Kong, Yangang Liu, +10

Blood

Mechanism governing a stem cell-generating <i>cis</i> -regulatory element

Rajendran Sanalkumar, Kirby D. Johnson, Xin Gao, +5

Proceedings of the National Academy of Sciences

p53 −/− synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia

Jingfang Zhang, Guangyao Kong, Adhithi Rajagopalan, +17

Blood

Notch1 Gene Mutations Target KRAS G12D-expressing CD8+ Cells and Contribute to Their Leukemogenic Transformation

Guangyao Kong, Juan Du, Yangang Liu, +5

Journal of Biological Chemistry

Kras G12d ModelHematological MalignancyKras G12dOncogenic KrasMixed-phenotype Acute Leukemia +11

Identification of the methylation preference region in heterogeneous nuclear ribonucleoprotein K by protein arginine methyltransferase 1 and its implication in regulating nuclear/cytoplasmic distribution

Yuan-I Chang, Sheng-Chieh Hsu, Gar-Yang Chau, +4

Biochemical and Biophysical Research Communications

ChromatinNatural SciencesGeneticsEpigenetic ChangeEpigenomics +9

Protein Arginine Methyltransferase 1 Interacts with and Activates p38α to Facilitate Erythroid Differentiation

Wei-Kai Hua, Yuan-I Chang, Chao-Ling Yao, +3

PLoS ONE