Jean-Claude Louis

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

Yi Luo, Brad Bolon, Steve Kahn et al. · Nature Neuroscience · 2001 · 991 citations

Neurodegenerative Diseases, Molecular Neuroscience, Alzheimer's Disease +13

AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties

Narender R. Gavva, Rami Tamir, Yusheng Qu et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 385 citations

Molecular Determinants of Vanilloid Sensitivity in TRPV1

Narender R. Gavva, Lana Klionsky, Yusheng Qu et al. · Journal of Biological Chemistry · 2004 · 355 citations · Full text

A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase

Brian D. Bennett, Paul Denis, Mitsuru Haniu et al. · Journal of Biological Chemistry · 2000 · 269 citations · Full text