Yoshiaki Hirashima

Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

Koji Sakai, Takeshi Nishikawa, Mihoshi Suefuji et al. · Biochemical and Biophysical Research Communications · 2003 · 325 citations

Pancreatic β-Cells, Mitochondrial Function, Biochemistry +10

Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway

Yoshiaki Hirashima, Kaku Tsuruzoe, Shintaro Kodama et al. · Journal of Endocrinology · 2003 · 91 citations · Full text

Phosphatidylinositol 3-Kinase/akt Pathway, Insulin Signaling, Receptor Tyrosine Kinase +16

Heterozygous knockout of the IRS-1 gene in mice enhances obesity-linked insulin resistance: a possible model for the development of type 2 diabetes

Atsuhisa Shirakami, Tomomi Toyonaga, Kaku Tsuruzoe et al. · Journal of Endocrinology · 2002 · 52 citations · Full text

Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes

Junji Kawashima, Kaku Tsuruzoe, Hiroyuki Motoshima et al. · Diabetologia · 2003 · 48 citations · Full text

Insulin Resistance, Metabolic Syndrome, 3T3-l1 Adipocytes +13

Sensitivity of MLL-rearranged AML cells to all-trans retinoic acid is associated with the level of H3K4me2 in the RARα promoter region

Kenichi Sakamoto, Toshihiko Imamura, Mio Yano et al. · Blood Cancer Journal · 2014 · 37 citations · Full text