Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

Krzysztof Palczewski, Takashi Kumasaka, Tetsuya Hori, +9

Science

Crystal StructurePhotoreceptor CellMolecular PhysiologyRetinaProtein Assembly +12

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H₂O₂ and Plays an Integral Role in Insulin Signal Transduction

Kalyankar Mahadev, Hiroyuki Motoshima, Xiangdong Wu, +5

Molecular and Cellular Biology

Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells

Daisuke Kukidome, Takeshi Nishikawa, Kazuhiro Sonoda, +7

Diabetes

Lipid PeroxidationManganese Superoxide DismutaseMetabolic RemodelingRedox BiologyInsulin Signaling +20

Involvement of AMP-Activated Protein Kinase in Glucose Uptake Stimulated by the Globular Domain of Adiponectin in Primary Rat Adipocytes

Xiangdong Wu, Hiroyuki Motoshima, Kalyankar Mahadev, +3

Diabetes

Insulin ReceptorMetabolic RemodelingGlobular AdiponectinInsulin SignalingGlucose Uptake +17

Differential Regulation of Adiponectin Secretion from Cultured Human Omental and Subcutaneous Adipocytes: Effects of Insulin and Rosiglitazone

Hiroyuki Motoshima, Xiangdong Wu, Madhur K. Sinha, +5

The Journal of Clinical Endocrinology & Metabolism

Metabolic DisorderAdipokinesInsulin SignalingObesityMetabolic Syndrome +21

Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL

Hiroyuki Motoshima, Xiangdong Wu, Kalyankar Mahadev, +1

Biochemical and Biophysical Research Communications

InflammationSuperoxide GenerationOxysterolEndothelial CellsBiochemistry +10

Adenosine Monophosphate-Activated Protein Kinase Suppresses Vascular Smooth Muscle Cell Proliferation Through the Inhibition of Cell Cycle Progression

Motoyuki Igata, Hiroyuki Motoshima, Kaku Tsuruzoe, +11

Circulation Research

Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells

R. Ouedraogo, Xiangdong Wu, Shi‐Qiong Xu, +6

Diabetes

Metabolic SyndromeReactive Oxygen SpeciesBiochemistryAdiponectin SuppressionMedicine +12

Statins Activate Peroxisome Proliferator-Activated Receptor γ Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase–Dependent Cyclooxygenase-2 Expression in Macrophages

Miyuki Yano, Takeshi Matsumura, Takafumi Senokuchi, +12

Circulation Research

Impact of mitochondrial ROS production in the pathogenesis of insulin resistance

Takeshi Nishikawa, Daisuke Kukidome, Kazuhiro Sonoda, +5

Diabetes Research and Clinical Practice

Insulin ResistanceMetabolic SyndromeInsulin SignalingBiochemistryMitochondrial Function +9