Thippeswamy Devasamudram

Novel <i>bis</i> -Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro

Yasuhiro Koh, Hirotomo Nakata, Kenji Maeda et al. · Antimicrobial Agents and Chemotherapy · 2003 · 365 citations · Full text

Immunology, Immunotherapeutics, Pharmacotherapy +17

<i>In vivo</i> inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors

Wan‐Pin Chang, Gerald Koelsch, Stephen T.C. Wong et al. · Journal of Neurochemistry · 2004 · 102 citations

Structure-based design of cycloamide–urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)

Arun K. Ghosh, Thippeswamy Devasamudram, Hong Lin et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 75 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Cycloamide–urethane-derived Novel Inhibitors +11

Design, Synthesis and X-ray Structure of Protein−Ligand Complexes:  Important Insight into Selectivity of Memapsin 2 (β-Secretase) Inhibitors

Arun K. Ghosh, Nagaswamy Kumaragurubaran, Hong Lin et al. · Journal of the American Chemical Society · 2006 · 57 citations · Full text

Protein-ligand Crystal Structure, Protein Assembly, Molecular Biology +18

Specificity of Memapsin 1 and Its Implications on the Design of Memapsin 2 (β-Secretase) Inhibitor Selectivity

Robert T. Turner, Jeffrey A. Loy, Chan Nguyen et al. · Biochemistry · 2002 · 52 citations