A human liver microphysiology platform for investigating physiology, drug safety, and disease models

Lawrence A. Vernetti, Nina Senutovitch, Robert C. Boltz, +4

Experimental Biology and Medicine

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

Sager J. Gosai, Joon Hyeok Kwak, Cliff J. Luke, +9

PLoS ONE

Drug TargetEngineeringMolecular BiologyBiomedical Engineeringα1-Antitrypsin Deficiency +14

Development of a 384-Well Colorimetric Assay to Quantify Hydrogen Peroxide Generated by the Redox Cycling of Compounds in the Presence of Reducing Agents

Paul A. Johnston, Karina M. Soares, Sunita N. Shinde, +5

Assay and Drug Development Technologies

Advanced Oxidation ProcessEngineeringChemistryHydrogen Peroxide GeneratedRedox Biology +17

Profiling the NIH Small Molecule Repository for Compounds That Generate H ₂ O ₂ by Redox Cycling in Reducing Environments

Karina M. Soares, Nicole L. Blackmon, Tong Ying Shun, +5

Assay and Drug Development Technologies

HTS Identifies Novel and Specific Uncompetitive Inhibitors of the Two-Component NS2B-NS3 Proteinase of West Nile Virus

Paul A. Johnston, Jennifer Phillips, Tong Ying Shun, +11

Assay and Drug Development Technologies

Wnv Ns2b-ns3proSpecific Uncompetitive InhibitorsViral PathogenesisImmunologyMolecular Biology +17

Identifying Actives from HTS Data Sets: Practical Approaches for the Selection of an Appropriate HTS Data-Processing Method and Quality Control Review

Tong Ying Shun, John S. Lazo, Elizabeth R. Sharlow, +1

SLAS DISCOVERY

Identification of Survival Genes in Human Glioblastoma Cells by Small Interfering RNA Screening

Nikhil G. Thaker, Fang Zhang, Peter R. McDonald, +4

Molecular Pharmacology

Development and optimization of high-throughput in vitro protein phosphatase screening assays

Marni Brisson Tierno, Paul A. Johnston, Caleb Foster, +4

Nature Protocols

BiochemistryMolecular Biological MethodMedicineNatural SciencesBioanalysis +6

Identifying and Quantifying Heterogeneity in High Content Analysis: Application of Heterogeneity Indices to Drug Discovery

Albert Gough, Ning Chen, Tong Ying Shun, +10

PLoS ONE

Pharmaceutical ResearchEngineeringHit IdentificationMultiomicsGene Expression Profiling +22

Applications of the microphysiology systems database for experimental ADME-Tox and disease models

Mark E. Schurdak, Lawrence A. Vernetti, Luke Bergenthal, +5

Lab on a Chip

EngineeringMps Disease ModelsBiomedical EngineeringBiomedical Signal AnalysisSystems Pharmacology +21