Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease

Jan Monti, Judith Fischer, Svetlana Paskaš, +21

Nature Genetics

Soluble Epoxide HydrolaseCardiomyopathyHeart FailureBiochemistryCardiovascular Disease +9

Inhibition of pressure natriuresis in mice lacking the AT2 receptor

Wolf-Hagen Schunck, Horst Honeck, Anna Franca Milia, +6

Kidney International

InflammationMolecular PharmacologySignal TransductionMolecular PhysiologySodium Homeostasis +8

Cytochrome P450-Dependent Eicosapentaenoic Acid Metabolites Are Novel BK Channel Activators

Birgit Lauterbach, Eduardo Barbosa‐Sicard, Mong-Heng Wang, +8

Hypertension

Characterization of then-Alkane and Fatty Acid Hydroxylating Cytochrome P450 Forms 52A3 and 52A4

Ulrich Scheller, Thomas Zimmer, Eva Kärgel, +1

Archives of Biochemistry and Biophysics

Chemical BiologyLipid AnalysisBiochemistryNatural SciencesBiochemical Genetics +2

Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization

Ryoji Yanai, Lama Mulki, Eiichi Hasegawa, +10

Proceedings of the National Academy of Sciences

17(<i>R</i>),18(<i>S</i>)-Epoxyeicosatetraenoic Acid, a Potent Eicosapentaenoic Acid (EPA) Derived Regulator of Cardiomyocyte Contraction: Structure–Activity Relationships and Stable Analogues

John R. Falck, Gerd Wallukat, P. Narender, +7

Journal of Medicinal Chemistry

Cardiac MusclePotent Eicosapentaenoic AcidLipid PeroxidationCardiovascular PharmacologyPharmacotherapy +17

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91phox to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock

Bahar Tunçtan, Belma Korkmaz, Ayse Nihal Sari, +10

Nitric Oxide

CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy

Christina Westphal, Bastian Spallek, Anne Konkel, +11

PLoS ONE

The Biological Actions of 11,12-Epoxyeicosatrienoic Acid in Endothelial Cells Are Specific to the R/S-Enantiomer and Require the Gs Protein

Yindi Ding, Timo Frömel, Rüdiger Popp, +3

Journal of Pharmacology and Experimental Therapeutics

Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization

Eiichi Hasegawa, Saori Inafuku, Lama Mulki, +16

Proceedings of the National Academy of Sciences