GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

Alice Biosa, Alžbeta Trančíková, Laura Civiero, +4

Human Molecular Genetics

Gtpase ActivityMolecular RegulationMolecular BiologySocial SciencesSignaling Pathway +18

LRRK2 Affects Vesicle Trafficking, Neurotransmitter Extracellular Level and Membrane Receptor Localization

Rossana Migheli, Maria Grazia Del Giudice, Ylenia Spissu, +11

PLoS ONE

Role of LRRK2 in the regulation of dopamine receptor trafficking

Mauro Rassu, Maria Grazia Del Giudice, Simona Sanna, +13

PLoS ONE

Sporadic ParkinsonNeurotransmitterCellular NeurobiologyDopamine Receptor TraffickingInternalization Mechanisms +15

The G2019S variant of leucine-rich repeat kinase 2 (LRRK2) alters endolysosomal trafficking by impairing the function of the GTPase RAB8A

Pilar Rivero-Ríos, María Romo-Lozano, Jesús Madero‐Pérez, +4

Journal of Biological Chemistry

G2019s VariantSignal TransductionAlters Endolysosomal TraffickingG Protein-coupled ReceptorNatural Sciences +8

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils

Isabella Russo, Alice Kaganovich, Jinhui Ding, +8

Neurobiology of Disease

InflammationNeuroinflammationNeurodegenerative DiseasesTranscriptome AnalysisSynaptic Signaling +13

Dopamine Oxidation Products as Mitochondrial Endotoxins, a Potential Molecular Mechanism for Preferential Neurodegeneration in Parkinson’s Disease

Alice Biosa, Irene Arduini, María Eugenia Soriano, +4

ACS Chemical Neuroscience

Mitochondrial BiologyRedox BiologySocial SciencesOxidative StressDopamine Oxidation Products +20

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

Lucia Iannotta, Alice Biosa, Jillian H. Kluss, +9

Cells

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1

María Dolores Pérez‐Carrión, Francesca Pischedda, Alice Biosa, +17

Frontiers in Molecular Neuroscience

Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss

Alice Biosa, Álvaro Sánchez-Martínez, Roberta Filograna, +6

Human Molecular Genetics

MitophagyToxic EffectsLipid PeroxidationCell DeathReactive Oxygen Species +17

LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation

Francesca Pischedda, Maria Daniela Cirnaru, Luisa Ponzoni, +10

Brain