Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

K M Mohler, Dauphine Torrance, Carole Smith, +5

The Journal of Immunology

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery

Mark Kennedy, Dauphine Torrance, Kathleen S. Picha, +1

The Journal of Immunology

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

João S. Silva, Philip Morrissey, K H Grabstein, +3

The Journal of Experimental Medicine

Immune RegulationImmunologyPathologyImmunologic MechanismFatal Infection +17

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor

Jürgen Müllberg, Fiona H. Durie, Carol Otten-Evans, +5

The Journal of Immunology

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

Paul D. Crowe, Barbara Walter, K M Mohler, +3

The Journal of Experimental Medicine

InflammationCytokineActivated T CellsSignal Transduction80-Kd Tnf Receptor +12

Poxvirus Genomes Encode a Secreted, Soluble Protein That Preferentially Inhibits β Chemokine Activity yet Lacks Sequence Homology to Known Chemokine Receptors

Craig A. Smith, Terri Smith, Pamela J. Smolak, +9

Virology

Chemokine BiologyKnown Chemokine ReceptorsViral ImmunityImmunologyPoxvirus Genomes Encode +9

Identification and Characterization of 4-[[4-(2-Butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3 S)thiomorpholinecarboxamide (TMI-1), a Novel Dual Tumor Necrosis Factor-α-Converting Enzyme/Matrix Metalloprotease Inhibitor for the Treatment of Rheumatoid Arthritis

Yuhua Zhang, Jun Xu, Jeremy I. Levin, +17

Journal of Pharmacology and Experimental Therapeutics

The discovery of anthranilic acid-Based MMP inhibitors. Part 2: SAR of the 5-position and P11 groups

Jeremy I. Levin, J. Chen, Mingyang Du, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetMedicineP11 GroupsAnti-cancer Agent +4

Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 2: SAR of the acetylenic P1′ group

Jeremy I. Levin, J.M Chen, Mingyang Du, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAcetylenic P1′ GroupPharmaceutical ScienceBiochemistryMedicine +9

Immune Function in Patients with Rheumatoid Arthritis Treated with Etanercept

Larry W. Moreland, R. Pat Bucy, Michael E. Weinblatt, +3

Clinical Immunology

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseRheumatic Diseases +7