Karen Roberts

CBP/p300 as a co-factor for the Microphthalmia transcription factor

Shoma Sato, Karen Roberts, Giorgio Gambino et al. · Oncogene · 1997 · 177 citations

Transcriptional Regulation, Microphthalmia Transcription Factor, Gene Expression +4

The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation

Jane Goodall, Claudia Wellbrock, Timothy J. Dexter et al. · Molecular and Cellular Biology · 2004 · 121 citations · Full text

Malignant Melanoma, Cancer Biology, Tumor Biology +16

Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2

Richard A. Ward, Nicola Colclough, Mairi Challinor et al. · Journal of Medicinal Chemistry · 2015 · 102 citations · Full text

Small Molecule Inhibitors, Covalent Inhibitors, Drug Target +17

Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC)

Richard A. Ward, Mark J. Anderton, Paul A. Bethel et al. · Journal of Medicinal Chemistry · 2019 · 75 citations · Full text

Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool

Richard Wang, Camilla Ascanelli, Ahmed Abdelbaki et al. · Communications Biology · 2021 · 60 citations · Full text