Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

Lenny van Bon, Alsya J. Affandi, Jasper Broen, +42

New England Journal of Medicine

Increased Frequency and Compromised Function of T Regulatory Cells in Systemic Sclerosis (SSc) Is Related to a Diminished CD69 and TGFβ Expression

Timothy R. D. J. Radstake, Lenny van Bon, Jasper Broen, +7

PLoS ONE

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

Timothy R. D. J. Radstake, Lenny van Bon, Jasper Broen, +7

PLoS ONE

The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis

Zana Brkić, Lenny van Bon, Marta Cossu, +13

Annals of the Rheumatic Diseases

Association of MicroRNA‐618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis

Marzia Rossato, Alsya J. Affandi, Soley Thordardottir, +19

Arthritis & Rheumatology

TLR2 Promotes Th2/Th17 Responses via TLR4 and TLR7/8 by Abrogating the Type I IFN Amplification Loop

Mark H. Wenink, Kim C. M. Santegoets, J. C. A. Broen, +9

The Journal of Immunology

Soluble Immune Complexes Shift the TLR-Induced Cytokine Production of Distinct Polarized Human Macrophage Subsets towards IL-10

Carmen A. Ambarus, Kim C. M. Santegoets, Lenny van Bon, +4

PLoS ONE

Earliest Phase of Systemic Sclerosis Typified by Increased Levels of Inflammatory Proteins in the Serum

Marta Cossu, Lenny van Bon, Carlo Preti, +3

Arthritis & Rheumatology

Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis

Alsya J. Affandi, Tiago Carvalheiro, Andrea Ottria, +15

Annals of the Rheumatic Diseases

Impaired dendritic cell proinflammatory cytokine production in psoriatic arthritis

Mark H. Wenink, Kim C. M. Santegoets, John Butcher, +6

Arthritis & Rheumatism