CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

Ania Skowera, Richard J. Ellis, Rubén Varela‐Calviño, +15

Journal of Clinical Investigation

Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation

Chung-Ching Chu, Niwa Ali, Panagiotis Karagiannis, +10

The Journal of Experimental Medicine

Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes

Anna Bulek, David K. Cole, Ania Skowera, +18

Nature Immunology

Type 1Autoimmune DiseaseHuman Beta CellsDiabetesImmunology +9

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

David K. Cole, Anna Bulek, Garry Dolton, +14

Journal of Clinical Investigation

Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers

Anna Lissina, Kristin Ladell, Ania Skowera, +13

Journal of Immunological Methods

Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition

David K. Cole, Emily S.J. Edwards, Katherine K. Wynn, +11

The Journal of Immunology

T-regulatory CellImmunologyAlter Tcr BindingMolecular BiologyImmunologic Mechanism +17

High levels of type 2 cytokine-producing cells in chronic fatigue syndrome

Ania Skowera, Anthony J. Cleare, Dorothy Blair, +3

Clinical & Experimental Immunology

Immune ActivationImmune RegulationImmunologyImmunologic MechanismImmune System +15

β-Cell–Specific CD8 T Cell Phenotype in Type 1 Diabetes Reflects Chronic Autoantigen Exposure

Ania Skowera, Kristin Ladell, James E. McLaren, +14

Diabetes

Circulating Preproinsulin Signal Peptide–Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill β-Cells

Deborah Kronenberg‐Versteeg, Robin R. Knight, Megan Estorninho, +10

Diabetes

Type 1Autoimmune DiseaseDiabetesImmune RegulationImmunology +13

Plasmacytoid Dendritic Cells Are Proportionally Expanded at Diagnosis of Type 1 Diabetes and Enhance Islet Autoantigen Presentation to T-Cells Through Immune Complex Capture

Jennifer S. Allen, Karl H. Pang, Ania Skowera, +8

Diabetes