Identification of four subsets of human CD3-CD16+ natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition.

Alessandro Moretta, Cristina Bottino, Daniela Pende, +7

The Journal of Experimental Medicine

Nk ClonesGl183- Nk CellsAutoimmune DiseaseSubset AssignmentAdaptive Immune System +13

Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2).

Ermanno Ciccone, Daniela Pende, O Viale, +7

The Journal of Experimental Medicine

HistocompatibilityHlaHla ImmunogeneticsImmunologyPathology +18

Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: definition of five distinct NK-determined allospecificities in humans.

Ermanno Ciccone, Daniela Pende, O Viale, +6

The Journal of Experimental Medicine

Adaptive Immune SystemImmunologyAntigen RecognitionNk CellsCell Repertoire +15

Alloantigen recognition by two human natural killer cell clones is associated with HLA-C or a closely linked gene.

Marco Colonna, Thomas A. Spies, Jack L. Strominger, +5

Proceedings of the National Academy of Sciences

HistocompatibilityHlaGeneticsHla ImmunogeneticsImmunology +18

Control of B cell lymphoma recognition via natural killer inhibitory receptors implies a role for human Vγ9/Vδ2 T cells in tumor immunity

Paul Fisch, Eva Meuer, Daniela Pende, +11

European Journal of Immunology

A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s).

Ermanno Ciccone, Silvano Ferrini, Cristina Bottino, +6

The Journal of Experimental Medicine

ImmunologyImmune RegulationImmunodominanceImmunologic MechanismAntigen Processing +16

Specific lysis of allogeneic cells after activation of CD3- lymphocytes in mixed lymphocyte culture.

Ermanno Ciccone, O Viale, Daniela Pende, +6

The Journal of Experimental Medicine

Allogeneic CellsAllergyLymphocyte DevelopmentSpecific LysisImmunology +13

Specific recognition of human CD3-CD16+ natural killer cells requires the expression of an autosomic recessive gene on target cells.

Emily J. Ciccone, Daniela Pende, O Viale, +7

The Journal of Experimental Medicine

ImmunologyImmunoeditingImmunologic MechanismCd4 T Cell ResponsesImmunotherapy +21

Self class I molecules protect normal cells from lysis mediated by autologous natural killer cells

Ermanno Ciccone, Daniela Pende, Massimo Vitale, +8

European Journal of Immunology

Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture.

Ermanno Ciccone, O Viale, Cristina Bottino, +6

The Journal of Experimental Medicine

Cell TherapyAllogeneic CellsCd3+ CellsSpecific LysisImmunology +13