Antisympathetic and hemodynamic property of a dual L/N-type Ca2+ channel blocker cilnidipine in rats

Akira Takahara, Hajime Koganei, Tomoko Takeda, +1

European Journal of Pharmacology

NeurophysiologyMedicineVascular PharmacologyPhysiologyHemodynamic Property +6

Structure–activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels

Takashi Yamamoto, Seiji Niwa, Seiji Ohno, +12

Bioorganic & Medicinal Chemistry Letters

Structure–activity Relationship StudyIon ChannelsOrganic ChemistryChemistryMedicine +1

Vascular Responsiveness to Various Vasoactive Substances After Exchange Transfusion with Pyridoxalated Hemoglobin Polyoxyethylene Conjugate (PHP) Solution in Anesthetized Rats

Yoshitoshi Kida, Seinosuke Iwata, Yuichi Gyoutoku, +3

Artificial Organs

Discovery, structure–activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity

Takashi Yamamoto, Seiji Niwa, Satoshi Iwayama, +10

Bioorganic & Medicinal Chemistry

Molecular PharmacologyCyproheptadine DerivativesHealth SciencesBiochemistryPharmacological Study +12

Effects of Pyridoxalated Hemoglobin Polyoxyethylene Conjugate and Other Hemoglobin‐Related Substances on Arterial Blood Pressure in Anesthetized and Conscious Rats

Yoshitoshi Kida, Midori Maeda, Seinosuke Iwata, +3

Artificial Organs

The structure–activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels

Takashi Yamamoto, Seiji Niwa, Seiji Ohno, +14

Bioorganic & Medicinal Chemistry Letters

BiochemistryStructure–activity Relationship StudyNatural SciencesIon ChannelsChemistry +3

Asymmetric synthesis and biological evaluations of (+)- and (−)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels

Takashi Yamamoto, Seiji Ohno, Seiji Niwa, +10

Bioorganic & Medicinal Chemistry Letters

Acid DerivativesCombinatorial ChemistryDerivativesBiochemistryNatural Sciences +8

Suppression of Formalin-Induced Nociception by Cilnidipine, a Voltage-Dependent Calcium Channel Blocker

Hajime Koganei, Masataka Shoji, Seinosuke Iwata

Biological and Pharmaceutical Bulletin

Rat Formalin ModelPain MedicineAnesthetic MechanismNeuropathic PainMolecular Pain +15

Rational Design, Synthesis, and Structure−Activity Relationships of Novel Factor Xa Inhibitors:  (2-Substituted-4-amidinophenyl)pyruvic and -propionic Acids

Kazuyuki Sagi, Tadakiyo Nakagawa, Masahiro Yamanashi, +20

Journal of Medicinal Chemistry

Combinatorial ChemistryChemical BiologyPharmaceutical Chemistry-Propionic AcidsMedicinal Chemistry +14

Behavioural studies in rats treated with monosodium l-glutamate during the early stages of life

Seinosuke Iwata, Masamichi Ichimura, Yoshimasa Matsuzawa, +2

Toxicology Letters

Psychoactive DrugEarly StagesNeurophysiologyBehavioral NeuroscienceMedicine +11