Different Effects of L/N-Type and L-Type Calcium Channel Blockers on the Renin-Angiotensin-Aldosterone System in SHR/Izm

Tomoyuki Konda, Azusa Enomoto, Shizuka Aritomi, +4

American Journal of Nephrology

Antisympathetic and hemodynamic property of a dual L/N-type Ca2+ channel blocker cilnidipine in rats

Akira Takahara, Hajime Koganei, Tomoko Takeda, +1

European Journal of Pharmacology

NeurophysiologyMedicineVascular PharmacologyPhysiologyHemodynamic Property +6

Structure–activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels

Takashi Yamamoto, Seiji Niwa, Seiji Ohno, +12

Bioorganic & Medicinal Chemistry Letters

Structure–activity Relationship StudyIon ChannelsOrganic ChemistryChemistryMedicine +1

Neuronal Ca2+ Channel Blocking Action of an Antihypertensive Drug, Cilnidipine, in IMR-32 Human Neuroblastoma Cells

Akira Takahara, Shin‐ichi Fujita, Keiko MOKI, +4

Hypertension Research

Antithrombotic activity of AT-1015, a potent 5-HT2A receptor antagonist, in rat arterial thrombosis model and its effect on bleeding time

Hideaki Kihara, Hajime Koganei, Ken Hirose, +2

European Journal of Pharmacology

ThrombosisCardiovascular DiseaseBleeding TimeMedicineBlood Platelet +11

Discovery, structure–activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity

Takashi Yamamoto, Seiji Niwa, Satoshi Iwayama, +10

Bioorganic & Medicinal Chemistry

Molecular PharmacologyCyproheptadine DerivativesHealth SciencesBiochemistryPharmacological Study +12

AT-1015, a Novel Serotonin (5-HT)2 Receptor Antagonist, Blocks Vascular and Platelet 5-HT2A Receptors and Prevents the Laurate-Induced Peripheral Vascular Lesion in Rats

Hideaki Kihara, Ken Hirose, Hajime Koganei, +6

Journal of Cardiovascular Pharmacology

ThrombosisBlood PlateletMedicinePlatelet AggregationPhysiology +12

The structure–activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels

Takashi Yamamoto, Seiji Niwa, Seiji Ohno, +14

Bioorganic & Medicinal Chemistry Letters

BiochemistryStructure–activity Relationship StudyNatural SciencesIon ChannelsChemistry +3

Asymmetric synthesis and biological evaluations of (+)- and (−)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels

Takashi Yamamoto, Seiji Ohno, Seiji Niwa, +10

Bioorganic & Medicinal Chemistry Letters

Acid DerivativesCombinatorial ChemistryDerivativesBiochemistryNatural Sciences +8

Suppression of Formalin-Induced Nociception by Cilnidipine, a Voltage-Dependent Calcium Channel Blocker

Hajime Koganei, Masataka Shoji, Seinosuke Iwata

Biological and Pharmaceutical Bulletin

Rat Formalin ModelPain MedicineAnesthetic MechanismNeuropathic PainMolecular Pain +15