Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance.

Erin L. Volk, Kate M. Farley, Yan Wu, +3

PubMed

Breast OncologyMolecular BiologyCancer BiologyTumor BiologyDrug Resistance +16

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter.

Erin L. Volk, Erasmus Schneider

PubMed

Breast OncologyMethotrexate Polyglutamate TransporterBcrp SubstrateCancer BiologyTumor Biology +19

The Product of the ABC Half-Transporter Gene ABCG2 (BCRP/MXR/ABCP) Is Expressed in the Plasma Membrane

Emmanuelle Rocchi, Alexey Khodjakov, Erin L. Volk, +4

Biochemical and Biophysical Research Communications

Molecular PhysiologySignal TransductionPlasma MembraneNatural SciencesMembrane Transport +11

Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States

Tara Alpert, Anderson F. Brito, Erica Lasek‐Nesselquist, +47

Cell

Virus EpidemiologySars-cov-2 Variant B.1.1.7MedicineCovid-19 PandemicVirus Transmission +5

Coordinated Action of Glutathione S-Transferases (GSTs) and Multidrug Resistance Protein 1 (MRP1) in Antineoplastic Drug Detoxification

Charles S. Morrow, Pamela K. Smitherman, Sri K. Diah, +2

Journal of Biological Chemistry

Lipid PeroxidationExpress Mrp1Redox BiologyGlutathione S-transferasesTumor Biology +15

Notch1 regulates the expression of the multidrug resistance gene<i>ABCC1</i>/<i>MRP1</i>in cultured cancer cells

Sungpil Cho, Meiling Lü, Xiaolong He, +5

Proceedings of the National Academy of Sciences

BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells

James Chih‐Hsin Yang, Erasmus Schneider, Min‐Liang Kuo, +2

Biochemical Pharmacology

Tumor BiologyBreast OncologyMedicineCancer Cell BiologyCancer Genomics +5

Cross-resistance to camptothecin analogues in a mitoxantrone-resistant human breast carcinoma cell line is not due to DNA topoisomerase I alterations.

James Chih‐Hsin Yang, Julie K. Horton, Kenneth H. Cowan, +1

PubMed

Tumor BiologyMcf7/wt CellsBreast OncologyOncogenic AgentMedicine +13

Amplification of 4q21-q22 and theMXR gene in independently derived mitoxantrone-resistant cell lines

Turid Knutsen, V. Koneti Rao, Thomas Ried, +11

Genes Chromosomes and Cancer

Tumor Necrosis Factor-α Increases the Steady-state Reduction of Cytochrome b of the Mitochondrial Respiratory Chain in Metabolically Inhibited L929 Cells

José A. Sánchez‐Alcázar, Erasmus Schneider, Miguel Ángel Martı́nez, +6

Journal of Biological Chemistry

Mitochondrial DysfunctionLipid PeroxidationCell DeathMitochondrial BiologyMetabolic Remodeling +19