The mutation spectrum revealed by paired genome sequences from a lung cancer patient

William Lee, Zhaoshi Jiang, Jinfeng Liu, +24

Nature

Paired Genome SequencesMutation SpectrumSomatic VariantTumor HeterogeneityMedicine +10

Evidence for Sequenced Molecular Evolution of <i>IDH1</i> Mutant Glioblastoma From a Distinct Cell of Origin

Albert Lai, Samir Kharbanda, Whitney B. Pope, +28

Journal of Clinical Oncology

Exon Array Profiling Detects <i>EML4-ALK</i> Fusion in Breast, Colorectal, and Non–Small Cell Lung Cancers

Eva Lin, Li Li, Yinghui Guan, +6

Molecular Cancer Research

PathologyEml4-alk FusionCancer BiologyTumor BiologyCancer Detection +16

Structural Basis for Substrate Selectivity in Human Maltase-Glucoamylase and Sucrase-Isomaltase N-terminal Domains

Lyann Sim, Carly Willemsma, Sankar Mohan, +3

Journal of Biological Chemistry

Phosphoinositide 3-Kinase (PI3K) Pathway Alterations Are Associated with Histologic Subtypes and Are Predictive of Sensitivity to PI3K Inhibitors in Lung Cancer Preclinical Models

Jill M. Spoerke, Carol O’Brien, Ling Huw, +13

Clinical Cancer Research

New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from <i>Salacia reticulata</i>

Lyann Sim, Kumarasamy Jayakanthan, Sankar Mohan, +4

Biochemistry

Terminal Starch ProductsNutraceutical IngredientGlycobiologyPolysaccharideNew Glucosidase Inhibitors +16

COP1 is a tumour suppressor that causes degradation of ETS transcription factors

Alberto C. Vitari, Kevin G. Leong, Kim Newton, +15

Nature

Transcriptional RegulationCell RegulationMedicineTranscription RegulationGene Regulation +8

Biomarker Analyses from a Placebo-Controlled Phase II Study Evaluating Erlotinib ± Onartuzumab in Advanced Non–Small Cell Lung Cancer: MET Expression Levels Are Predictive of Patient Benefit

Hartmut Koeppen, Wei Yu, Jiping Zha, +25

Clinical Cancer Research

Functional Genomics Identifies ABCC3 as a Mediator of Taxane Resistance in HER2-Amplified Breast Cancer

Carol O’Brien, Guy Cavet, Ajay Pandita, +8

Cancer Research

Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides

Sunil K. Sukumaran, Karen K. Yee, Shusuke Iwata, +8

Proceedings of the National Academy of Sciences