Molecular genetic epidemiology of homozygous familial hypercholesterolemia in the Hokuriku district of Japan

Hiroshi Mabuchi, Atsushi Nohara, Tohru Noguchi, +8

Atherosclerosis

Hokuriku DistrictMetabolic SyndromeMolecular Genetic EpidemiologyGenetic DeterminantHomozygous Familial Hypercholesterolemia +10

Genotypic and phenotypic features in homozygous familial hypercholesterolemia caused by proprotein convertase subtilisin/kexin type 9 (PCSK9) gain-of-function mutation

Hiroshi Mabuchi, Atsushi Nohara, Tohru Noguchi, +13

Atherosclerosis

Lipid DisorderHomozygous Familial HypercholesterolemiaGenetic DisorderGeneticsInherited Metabolic Disease +10

Cleavage of Hepatitis C Virus Nonstructural Protein 5A by a Caspase-like Protease(s) in Mammalian Cells

Shinya Satoh, Masami Hirota, Tohru Noguchi, +3

Virology

Virus StructureViral ReplicationMolecular VirologyViral HepatitisMedicine +8

The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation

Tohru Noguchi, Shoji Katsuda, Masa‐aki Kawashiri, +6

Atherosclerosis

Metabolic SyndromeLipid DisorderPcsk9 FunctionCardiovascular DiseaseFamilial Hypercholesterolaemia +9

Regulation of Glucocorticoid Receptor Transcription and Nuclear Translocation during Single and Repeated Immobilization Stress

Tohru Noguchi, Shinya Makino, Reiko Matsumoto, +4

Endocrinology

Reduced Glucocorticoid ReceptorMolecular RegulationGlucocorticoidGlucocorticoid Receptor TranscriptionTranscriptional Regulation +18

Effects of Mutation in Hepatitis C Virus Nonstructural Protein 5A on Interferon Resistance Mediated by Inhibition of PKR Kinase Activity in Mammalian Cells

Tohru Noguchi, Shinya Satoh, Takeshi Noshi, +6

Microbiology and Immunology

A novel type of familial hypercholesterolemia: Double heterozygous mutations in LDL receptor and LDL receptor adaptor protein 1 gene

Hayato Tada, Masa‐aki Kawashiri, Rumiko Ohtani, +9

Atherosclerosis

Metabolic SyndromeFamilial HypercholesterolemiaLipid DisorderNovel TypeGenetic Disorder +9

Altered Metabolism of Low-Density Lipoprotein and Very-Low-Density Lipoprotein Remnant in Autosomal Recessive Hypercholesterolemia

Hayato Tada, Masa‐aki Kawashiri, Katsunori Ikewaki, +13

Circulation Cardiovascular Genetics

Effect of Stress and Adrenalectomy on Urocortin II mRNA Expression in the Hypothalamic Paraventricular Nucleus of the Rat

Yasushi Tanaka, Shinya Makino, Tohru Noguchi, +3

Neuroendocrinology

Food IntakeImmobilization StressSocial SciencesAdrenal GlandHypothalamic Paraventricular Nucleus +14

Comparison of effects of bezafibrate and fenofibrate on circulating proprotein convertase subtilisin/kexin type 9 and adipocytokine levels in dyslipidemic subjects with impaired glucose tolerance or type 2 diabetes mellitus: Results from a crossover study

Tohru Noguchi, Junji Kobayashi, Kunimasa Yagi, +11

Atherosclerosis

ObesityMetabolic SyndromeBody CompositionMetabolic DisorderCardiovascular Disease +11