The E32K variant of PCSK9 exacerbates the phenotype of familial hypercholesterolaemia by increasing PCSK9 function and concentration in the circulation

Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

Jonathan C. Cohen, Eric Boerwinkle, Thomas H. Mosley et al. · New England Journal of Medicine · 2006 · 3.1K citations · Full text

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

Marianne Abifadel, Mathilde Varret, Jean‐Pierre Rabès et al. · Nature Genetics · 2003 · 3K citations

Genetic Disorder, Genetics, Pathology +4

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation

Nabil G. Seidah, Suzanne Benjannet, L. Alexandra Wickham et al. · Proceedings of the National Academy of Sciences · 2003 · 1.2K citations · Full text

Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation

Dawei Zhang, Thomas A. Lagace, Rita Garuti et al. · Journal of Biological Chemistry · 2007 · 773 citations · Full text

Decreased plasma cholesterol and hypersensitivity to statins in mice lacking <i>Pcsk9</i>

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