Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs

Paola Lembo, Eric Grazzini, Thierry Groblewski, +17

Nature Neuroscience

Synaptic PlasticityNew FamilyMolecular NeuroscienceSignal TransductionSensory Neuroscience +13

Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat

Martin Perkins, Elizabeth A. Campbell, Andy Dray

Pain

Specific B1 AntagonistPain MedicineImmunologyBradykinin B1Neuropathic Pain +18

Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 1. The aromatic "A-region"

Christopher Walpole, Roger Wrigglesworth, Stuart Bevan, +6

Journal of Medicinal Chemistry

Knockdown of spinal metabotropic glutamate receptor 1 (mGluR₁) alleviates pain and restores opioid efficacy after nerve injury in rats

Marian E. Fundytus, Kiran Yashpal, Jean‐Guy Chabot, +5

British Journal of Pharmacology

Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region"

Christopher Walpole, Roger Wrigglesworth, Stuart Bevan, +6

Journal of Medicinal Chemistry

Pharmaceutical ScienceNeuropeptidesPain MedicineMolecular PainPharmacotherapy +16

Inflammation and hyperalgesia: highlighting the team effort

Andy Dray, Stuart Bevan

Trends in Pharmacological Sciences

InflammationPain SyndromeHealth SciencesTeam EffortAcute Pain +4

In vivo antinociceptive activity of anti-rat mGluR1 and mGluR5 antibodies in rats

Marian E. Fundytus, Kim Fisher, Andy Dray, +2

Neuroreport

Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro

László Urbán, Andy Dray

Neuroscience Letters

Spinal Cord InjuryPharmacological StudyNovel Capsaicin AntagonistPain MedicineMedicine +5

Analogs of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region"

Christopher Walpole, Roger Wrigglesworth, Stuart Bevan, +6

Journal of Medicinal Chemistry

Pharmaceutical SciencePain MedicineAltmetric Attention ScorePharmacotherapyPharmaceutical Chemistry +16

Analogues of Capsaicin with Agonist Activity as Novel Analgesic Agents:  Structure−Activity Studies. 4. Potent, Orally Active Analgesics

Roger Wrigglesworth, Christopher Walpole, Stuart Bevan, +6

Journal of Medicinal Chemistry

Pharmaceutical SciencePain MedicineActive AnalgesicsPharmacotherapyPharmaceutical Chemistry +16