The mechanism of lack of hypocholesterolemic effects of pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, in rats

Tomoyuki Fujioka, Futoshi Nara, Yoshio Tsujita, +3

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Hypocholesterolemic EffectsMetabolic SyndromePravastatin SodiumOxysterolBiochemistry +11

Structure of complestatin, a very strong inhibitor of protease activity of complement in the human complement system

Haruo Seto, Tomoyuki Fujioka, Kazuo Furihata, +2

Tetrahedron Letters

Complement SystemAutoimmune DiseaseBiochemistryStrong InhibitorMedicine +6

Alutacenoic Acids A and B, Rare Naturally Occurring Cyclopropenone Derivatives Isolated from Fungi:  Potent Non-Peptide Factor XIIIa Inhibitors

Hiroshi Kogen, Toshihiro Kiho, Keiko Tago, +5

Journal of the American Chemical Society

Molecular PharmacologyMedicinal ChemistryAlutacenoic Acids AHeterocyclicBiochemistry +12

Epi-cochlioquinone A, a Novel Acyl-CoA: Cholesterol Acyltransferase Inhibitor Produced by Stachybotrys bisbyi.

Tomoyuki Fujioka, Keiko Yao, KIYOSHI HAMANO, +7

The Journal of Antibiotics

Schizostatin, a Novel Squalene Synthase Inhibitor Produced by the Mushroom, Schizophyllum commune. I. Taxonomy, Fermentation, Isolation, Physico-chemical Properties and Biological Activities.

Tatsuo Tanimoto, Kaori Onodera, Tsuyoshi Hosoya, +7

The Journal of Antibiotics

(8S)-(glutathion-S-yl)dihydromorphinone, a novel metabolite of morphine from guinea pig bile.

Takashi Ishida, Yoshito Kumagai, Yoshito Ikeda, +7

Drug Metabolism and Disposition

Conformational analysis and docking study of potent factor XIIIa inhibitors having a cyclopropenone ring

Yoriko Iwata, Keiko Tago, Toshihiro Kiho, +6

Journal of Molecular Graphics and Modelling

Molecular DockingMedicinal ChemistryBioorganic ChemistryBiochemistryMedicine +10

Importance of acyl-coenzyme A:cholesterol acyltransferase 1/2 dual inhibition for anti-atherosclerotic potency of pactimibe

Ken Kitayama, Tatsuo Tanimoto, Teiichiro Koga, +3

European Journal of Pharmacology

Anti-atherosclerotic PotencyOxysterolBiochemistryDual InhibitionMedicine +9

Complement receptors in atherosclerotic lesions.

Eiji Saito, Tomoyuki Fujioka, Hiroko Kanno, +6

PubMed

InflammationComplement SystemVascular DiseaseVasculitisPhysiology +10

Pactimibe stabilizes atherosclerotic plaque through macrophage acyl-CoA:cholesterol acyltransferase inhibition in WHHL rabbits

Ken Kitayama, Teiichiro Koga, Naoyuki Maeda, +2

European Journal of Pharmacology

InflammationVascular DiseaseBiochemistryCardiovascular DiseaseAtherosclerosis +10