Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice

Tiziana Genovese, Rosanna Di Paola, Paolo N. Catalano, +6

Critical Care Medicine

Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors

Jia-He Li, L.S. Serdyuk, Dana Ferraris, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineDrug DevelopmentPharmacologySubstituted 5 +1

Synthesis of <i>N</i>-Glyoxyl Prolyl and Pipecolyl Amides and Thioesters and Evaluation of Their In Vitro and In Vivo Nerve Regenerative Effects

Gregory S. Hamilton, Yong-Qian Wu, David C. Limburg, +16

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistrySmall Molecule LigandsChemical BiologyPharmaceutical Chemistry +16

PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion

Salvatore Cuzzocrea, Rosanna Di Paola, Emanuela Mazzon, +8

The FASEB Journal

Gastrointestinal PharmacologyImmunologyGastroenterologyPathologySurgery +19

GPI 6150 Prevents H2O2 Cytotoxicity by Inhibiting Poly(ADP-ribose) Polymerase

Jie Zhang, Susan Lautar, Shirley Huang, +3

Biochemical and Biophysical Research Communications

BiochemistryOncogenic AgentCell DeathAnti-cancer AgentGpi 6150

GPI 6150, a PARP inhibitor, reduces the colon injury caused by dinitrobenzene sulfonic acid in the rat

Emanuela Mazzon, Laura Dugo, Jia-He Li, +5

Biochemical Pharmacology

InflammationColon InjuryAnti-inflammatoryMedicineGastroenterology +9

Role of poly(ADP-ribose) glycohydrolase in the development of inflammatory bowel disease in mice

Salvatore Cuzzocrea, Emanuela Mazzon, Tiziana Genovese, +7

Free Radical Biology and Medicine

InflammationChronic Inflammatory DiseasesInflammatory DiseaseAutoimmune DiseaseGlycobiology +7

Beneficial Effects Of GPI 6150, an Inhibitor of Poly(ADP-Ribose) Polymerase in a Rat Model of Splanchnic Artery Occlusion and Reperfusion

Emanuela Mazzon, Laura Dugo, Angelina De Sarro, +4

Shock

Vascular DiseaseNew PolySao ShockRat ModelInflammation +14

Poly(ADP-Ribose) Glycohydrolase Activity Mediates Post-Traumatic Inflammatory Reaction after Experimental Spinal Cord Trauma

Salvatore Cuzzocrea, Tiziana Genovese, Emanuela Mazzon, +11

Journal of Pharmacology and Experimental Therapeutics

Characterization of Competitive Inhibitors for the Transferase Activity of Pseudomonas aeruginosa Exotoxin A

Souzan Armstrong, Jia-He Li, Jie Zhang, +1

Journal of Enzyme Inhibition and Medicinal Chemistry

Aldo-keto ReductaseAdprt ReactionTransferase ActivityBioanalysisCompetitive Inhibitors +16