Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

Zhening Zhang, Wenguang Liang, L.J. Bailey, +18

eLife

Protein AssemblyMolecular BiologyProtein RefoldingInsulin SignalingProtein Folding +16

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Rebecca Deprez‐Poulain, Nathalie Hennuyer, Damien Bosc, +27

Nature Communications

Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination

L.J. Bailey, Kimberly M. Sheehy, Pawel K. Dominik, +8

Journal of Molecular Biology

Protein AssemblyBiochemistryProtein FoldingAntibody Fab FragmentsNatural Sciences +8

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3

Wenguang Liang, Catherine G. Triandafillou, Teng‐Yi Huang, +5

Proceedings of the National Academy of Sciences

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

Lauren A. McCord, Wenguang Liang, Evan Dowdell, +5

Proceedings of the National Academy of Sciences

Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease

John V. Lin King, Wenguang Liang, Kathryn P. Scherpelz, +3

Structure

Protein FunctionBiochemistryProtein FoldingNatural SciencesMedicine +8

In vivo epidermal migration requires focal adhesion targeting of ACF7

Jiping Yue, Yao Zhang, Wenguang Liang, +9

Nature Communications

Degradation of Alzheimer’s Amyloid-β by a Catalytically Inactive Insulin-Degrading Enzyme

Bikash R. Sahoo, Pritam Kumar Panda, Wenguang Liang, +3

Journal of Molecular Biology

Neurodegenerative DiseasesAlzheimer's DiseaseBiochemistryProtein FoldingMedicine +6

Conversion of <scp>d</scp> ‐ribulose 5‐phosphate to <scp>D</scp> ‐xylulose 5‐phosphate: new insights from structural and biochemical studies on human RPE

Wenguang Liang, Songying Ouyang, Neil Shaw, +3

The FASEB Journal

ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics

Yanlei Ma, Jiping Yue, Yao Zhang, +14

Nature Communications