Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca2+/calmodulin-dependent kinase kinase peptide

H. Kurokawa, Masanori Osawa, Hiroyuki Kurihara, +5

Journal of Molecular Biology

Coumarin and Chromen-4-one Analogues as Tautomerase Inhibitors of Macrophage Migration Inhibitory Factor: Discovery and X-ray Crystallography

Masaya Orita, Satoshi Yamamoto, Naoko Katayama, +11

Journal of Medicinal Chemistry

X-ray CrystallographyCrystal StructureBioorganic ChemistryMolecular BiologyChemical Biology +17

Comparative Base Specificity, Stability, and Lectin Activity of Two Lectins from Eggs of Rana catesbeiana and R. japonica and Liver Ribonuclease from R. catesbeiana

Yukie Okabe, Naoko Katayama, Masanori Iwama, +11

The Journal of Biochemistry

The Discovery of YM-60828: A Potent, Selective and Orally-Bioavailable Factor Xa Inhibitor

Fukushi Hirayama, Hiroyuki Koshio, Naoko Katayama, +8

Bioorganic & Medicinal Chemistry

BiochemistryMedicineMechanism Of ActionPharmacotherapyDrug Development +3

d-3-Hydroxybutyrate Dehydrogenase from Pseudomonas fragi: Molecular Cloning of the Enzyme Gene and Crystal Structure of the Enzyme

Kiyoshi Ito, Y. Nakajima, Emi Ichihara, +4

Journal of Molecular Biology

Crystal StructureAldehyde DehydrogenaseBiochemistryEnzyme GeneStructure-function Enzyme Kinetics +5

Primary Structure of a Ribonuclease from Bullfrog (Rana catesbeiana) Liver1

Reiko Nitta, Naoko Katayama, Yukie Okabe, +6

The Journal of Biochemistry

Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors

Hiroyuki Koshio, Fukushi Hirayama, Tsukasa Ishihara, +12

Bioorganic & Medicinal Chemistry

Biological ActivityBiochemistryMedicineNatural SciencesAnti-cancer Agent +5

Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a

Kenichi Onda, Takayuki Suzuki, Ryota Shiraki, +8

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural Sciences5-Chloro-n-aryl-1h-indole-2-carboxamide DerivativesPharmacology +2

Design, synthesis and biological activity of YM-60828 derivatives: potent and orally-Bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates

Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara, +14

Bioorganic & Medicinal Chemistry

Biological ActivityMedicinal ChemistryPharmaceutical ScienceBiochemistryNatural Sciences +10

Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template

Fukushi Hirayama, Hiroyuki Koshio, Naoko Katayama, +11

Bioorganic & Medicinal Chemistry

Biological ActivityMedicinal ChemistryBiochemistryBenzothiadiazine-4-one TemplateMedicine +7