Jean‐Maurice Dumont

The non‐immunosuppressive cyclosporin DEBIO‐025 is a potent inhibitor of hepatitis C virus replication in vitro†

Jan Paeshuyse, Artur Kaul, Erik De Clercq et al. · Hepatology · 2006 · 276 citations · Full text

Life Sciences, Microbiology, Molecular Biology +16

The cyclophilin inhibitor Debio-025 shows potent anti–hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus

Robert Flisiak, Andrzej Horban, Philippe Gallay et al. · Hepatology · 2008 · 223 citations

Pharmacy, Pharmacology, Pharmacotherapy +14

Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice

Ludovic Gomez, Hélène Thibault, Adbdallah Gharib et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2007 · 184 citations

Life Sciences, Cardiology, Pharmacology +17

The Nonimmunosuppressive Cyclosporin Analogs NIM811 and UNIL025 Display Nanomolar Potencies on Permeability Transition in Brain-Derived Mitochondria

Magnus J. Hansson, Gustav Mattiasson, Roland Månsson et al. · Journal of Bioenergetics and Biomembranes · 2004 · 138 citations

Life Sciences, Medicinal Chemistry, Neuroscience +15

Debio 025, a Cyclophilin Binding Molecule, Is Highly Efficient in Clearing Hepatitis C Virus (HCV) Replicon-Containing Cells When Used Alone or in Combination with Specifically Targeted Antiviral Therapy for HCV (STAT-C) Inhibitors

Lotte Coelmont, Suzanne J. F. Kaptein, Jan Paeshuyse et al. · Antimicrobial Agents and Chemotherapy · 2008 · 125 citations · Full text

Medicine, Infectious Diseases, Pharmacology +17