IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Gαq interaction and protein kinase C-α/CaMKII activation in H9c2 cardiomyoblast cells

Chun‐Hsien Chu, Bor‐Show Tzang, Li-Mien Chen, +7

Journal of Endocrinology

Thymoquinone Induces Caspase-Independent, Autophagic Cell Death in CPT-11-Resistant LoVo Colon Cancer via Mitochondrial Dysfunction and Activation of JNK and p38

Ming-Cheng Chen, N. Lee, Hsi-Hsien Hsu, +7

Journal of Agricultural and Food Chemistry

Mitochondrial DysfunctionApoptosisImmunologyCell DeathPathology +17

Thymoquinone Induces Apoptosis in Oral Cancer Cells Through P38β Inhibition

Ehab Abdelfadil, Ya-Hsin Cheng, Da‐Tian Bau, +8

The American Journal of Chinese Medicine

Chemoprevention StrategyApoptosisCell DeathPathologyP38 Mapk +15

Activation of Insulin-Like Growth Factor II Receptor Induces Mitochondrial-Dependent Apoptosis through Gαq and Downstream Calcineurin Signaling in Myocardial Cells

Chun‐Hsien Chu, Bor‐Show Tzang, Li-Mien Chen, +8

Endocrinology

ApoptosisCell DeathIgf-ii ReceptorCellular PhysiologyInsulin Signaling +16

Effects of short- and long-term hypobaric hypoxia on Bcl2 family in rat heart

Shin‐Da Lee, Wei‐Wen Kuo, Chieh‐Hsi Wu, +9

International Journal of Cardiology

Bcl2 FamilyPhysiologyHypoxia (Medicine)Rat HeartLong-term Hypobaric Hypoxia +1

PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K–Akt–MDM2 signaling suppression

Tran Duc Dung, Cecilia Hsuan Day, Truong Viet Binh, +8

Food and Chemical Toxicology

Cancer ResearchHa22t Cell ProliferationSignaling PathwayCell RegulationMedicine +11

Lipopolysaccharide upregulates uPA, MMP-2 and MMP-9 via ERK1/2 signaling in H9c2 cardiomyoblast cells

Yi‐Chang Cheng, Li-Mien Chen, Mu-Hsin Chang, +7

Molecular and Cellular Biochemistry

CardiomyopathyMolecular PhysiologySignal TransductionSignaling PathwayCell Regulation +7

Rhubarb inhibits hepatocellular carcinoma cell metastasis via GSK-3-β activation to enhance protein degradation and attenuate nuclear translocation of β-catenin

Kun-Hsi Tsai, Hau-Hsueh Hsien, Li-Mien Chen, +7

Food Chemistry

Tumor BiologyAttenuate Nuclear TranslocationMedicineCancer Cell BiologyCancer Biology +8

17β-Estradiol reduces cardiac hypertrophy mediated through the up-regulation of PI3K/Akt and the suppression of calcineurin/NF-AT3 signaling pathways in rats

Chieh‐Hsi Wu, Jer-Yuh Liu, Jia‐Ping Wu, +10

Life Sciences

Cardiac MuscleCardiomyopathyMolecular PhysiologySignal TransductionCell Signaling +8

Leu27IGF2 plays an opposite role to IGF1 to induce H9c2 cardiomyoblast cell apoptosis via Gαq signaling

Ray‐Jade Chen, His-Chin Wu, Mu-Hsin Chang, +9

Journal of Molecular Endocrinology