Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.

Shin Takasawa, Akira Tohgo, Naoya Noguchi, +5

Journal of Biological Chemistry

BiosynthesisBiochemistryCyclic Adp-riboseCell SignalingNatural Sciences +12

Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

Takashi Watanabe, Yutaka Yonemura, H. Yonekura, +7

Proceedings of the National Academy of Sciences

Reg ProteinMetabolic SyndromeIslet TransplantationInsulin ManagementDiabetes +13

Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene.

Toshio Watanabe, H. Yonekura, K Terazono, +2

Journal of Biological Chemistry

GeneticsPancreatic Thread ProteinGene CharacterizationMolecular GeneticsProtein Genetics +16

Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome

Michiaki Unno, H. Yonekura, K. Nakagawara, +6

Journal of Biological Chemistry

Reg IiMouse Reg GenesGallbladder RegKnockout MouseFunctional Genomics +13

Expression of reg protein in rat regenerating islets and its co-localization with insulin in the Beta cell secretory granules

K Terazono, Yasuo Uchiyama, Misao Ide, +4

Diabetologia

Reg ProteinSignal TransductionPhysiologyMetabolic RegulationSecretory Granules +6

Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.

Akira Tohgo, Shin Takasawa, Naoya Noguchi, +6

Journal of Biological Chemistry

Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo.

I. Kato, Y. Suzuki, Atsuya Akabane, +6

Journal of Biological Chemistry

ImmunologyTransgenic MiceGlucose ToleranceInsulin SignalingGastrointestinal Peptide Hormone +16

Mosaic evolution of prepropancreatic polypeptide. II. Structural conservation and divergence in pancreatic polypeptide gene.

H. Yonekura, Koji Nata, T. Watanabe, +3

Journal of Biological Chemistry

Nicotinamide Inhibits IRF-1 mRNA Induction and Prevents IL-1β-Induced Nitric Oxide Synthase Expression in Pancreatic β Cells

Atsuya Akabane, I. Kato, Shin Takasawa, +4

Biochemical and Biophysical Research Communications

InflammationSignal TransductionReactive Nitrogen SpecieCell SignalingMedicine +8

Li ion conductivity of solid electrolyte, LiMInBr (M=Mg, Ca, Sr, Ba)

Yasuhiko Tomita, Hideyoshi Matsushita, H. Yonekura, +3

Solid State Ionics

Materials EngineeringMaterials ScienceSolid-state IonicSolid ElectrolyteEngineering +9