Amedea Mencarelli

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

F Grignani, Pier Francesco Ferrucci, Ugo Testa et al. · Cell · 1993 · 607 citations

Hematological Malignancy, Mixed-phenotype Acute Leukemia, Hematology +8

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

P P Pandolfi, F Grignani, Myriam Alcalay et al. · PubMed · 1991 · 289 citations

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

Pier Paolo Pandolfi, Myriam Alcalay, M Fagioli et al. · The EMBO Journal · 1992 · 273 citations · Full text

Hematological Malignancy, Genetics, Pathology +9

Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.

Myriam Alcalay, D Zangrilli, P P Pandolfi et al. · Proceedings of the National Academy of Sciences · 1991 · 250 citations · Full text

Hematological Malignancy, Chromatin, Reciprocal Balanced Translocation +15

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.

Letizia Longo, P P Pandolfi, Andrea Biondi et al. · The Journal of Experimental Medicine · 1990 · 208 citations · Full text

Acute Promyelocytic Leukemias, Mixed-phenotype Acute Leukemia, Genetics +16