Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide

Iori Ueki, Heather B. Roman, Alessandro Valli, +5

American Journal of Physiology-Endocrinology and Metabolism

Cysteine HomeostasisLipid PeroxidationRedox BiologyOxidative StressSevere Impairment +14

The Cysteine Dioxgenase Knockout Mouse: Altered Cysteine Metabolism in Nonhepatic Tissues Leads to Excess H ₂ S/HS ⁻ Production and Evidence of Pancreatic and Lung Toxicity

Heather B. Roman, Lawrence L. Hirschberger, Jakub Krijt, +3

Antioxidants and Redox Signaling

Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase

Iori Ueki, Heather B. Roman, Lawrence L. Hirschberger, +2

American Journal of Physiology-Endocrinology and Metabolism

Plasma Cysteine LevelsLipid PeroxidationExtrahepatic TissuesBody Cysteine LevelsLiver-specific Knockout +18

Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate–cysteine ligase subunits

Angelos K. Sikalidis, Kevin M. Mazor, Jeong-In Lee, +3

Amino Acids

Acid DeprivationBiochemistryPhysiologyBiochemical GeneticsMetabolism +5

Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate

Halina Jurkowska, Heather B. Roman, Lawrence L. Hirschberger, +5

Amino Acids

Lipid PeroxidationRedox BiologyCarbonyl MetabolismOxidative StressInflammation +14

Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility

Atsushi Asano, Heather B. Roman, Lawrence L. Hirschberger, +5

FEBS Journal

Propargylglycine inhibits hypotaurine/taurine synthesis and elevates cystathionine and homocysteine concentrations in primary mouse hepatocytes

Halina Jurkowska, Martha H. Stipanuk, Lawrence L. Hirschberger, +1

Amino Acids

Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo

Halina Jurkowska, Julie Niewiadomski, Lawrence L. Hirschberger, +6

Amino Acids

Endocrine MechanismMedicineLiver PhysiologyImmunologyMetabolic Regulation +7

Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice

Julie Niewiadomski, James Q. Zhou, Heather B. Roman, +4

Annals of the New York Academy of Sciences

Elevated Cysteine LevelsEnergy BalanceCaloric RestrictionOxidative StressMetabolic Syndrome +21

Insights into Taurine Synthesis and Function Based on Studies with Cysteine Dioxygenase (CDO1) Knockout Mice

Martha H. Stipanuk, Halina Jurkowska, Heather B. Roman, +2

Advances in experimental medicine and biology

Knockout MouseOxysterolCysteine DioxygenaseBiochemistryMedicine +8