Organ aging signatures in the plasma proteome track health and disease

Hamilton Oh, Jarod Rutledge, Daniel Nachun, +33

Nature

Atlas of the aging mouse brain reveals white matter as vulnerable foci

Oliver Hãhn, Aulden Foltz, Micaiah Atkins, +16

Cell

Vulnerable FociAlzheimer's DiseaseAgingWhite MatterDegenerative Pathology +5

Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

Jorge Urresti, Pan Zhang, Patricia Moran‐Losada, +14

Molecular Psychiatry

Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling

Megha Amar, Akula Bala Pramod, Nam‐Kyung Yu, +17

Molecular Psychiatry

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Ching‐Chieh Chou, Ryan T. Vest, Miguel A. Prado, +12

Nature Cell Biology

THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier

Shashank Saran, Doan Duy Hai Tran, Sabine Klebba-Färber, +8

BMC Cell Biology

Large-scale plasma proteomic profiling unveils diagnostic biomarkers and pathways for Alzheimer’s disease

Gyujin Heo, Ying Xu, Erming Wang, +34

Nature Aging

Cortical Organoids Model Early Brain Development Disrupted by 16p11.2 Copy Number Variants in Autism

Jorge Urresti, Pan Zhang, Patricia Moran‐Losada, +14

Brain DevelopmentGeneticsCerebral OrganoidCellular NeurobiologyDevelopmental Neuroscience +18

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Ching‐Chieh Chou, Ryan T. Vest, Miguel A. Prado, +12

Disruption of the cerebrospinal fluid–plasma protein balance in cognitive impairment and aging

Amelia Farinas, Jarod Rutledge, Veronica Augustina Bot, +15

Nature Medicine