Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.

P. Charles Lin, Sabita Sankar, Si Qing Shan, +4

PubMed

ImmunologyTumor BiologyTumor AngiogenesisAngiogenesisReceptor Tyrosine Kinase +18

REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase

Samiksha Katiyar, Enbo Liu, Christine A. Knutzen, +7

EMBO Reports

Signal TransductionSignaling PathwayMolecular PathwayCell RegulationNatural Sciences +8

Expression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor β2

Sabita Sankar, Negar Mahooti-Brooks

Journal of Biological Chemistry

HCPTPA, a Protein Tyrosine Phosphatase That Regulates Vascular Endothelial Growth Factor Receptor-mediated Signal Transduction and Biological Activity

Liwen Huang, Sabita Sankar, Christopher D. Kontos, +8

Journal of Biological Chemistry

Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin, +29

Journal of Medicinal Chemistry

Drug TargetKinase InhibitorsPharmacotherapyPharmaceutical ChemistryTumor Biology +14

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth <i>in vitro</i>

Toshiya Tsuji, Lisa M. Sapinoso, Tam Tran, +6

Oncotarget

Dual InhibitorDna DamageMolecular BiologyCell DeathDna-dependent Protein Kinase +14

CC-223, a Potent and Selective Inhibitor of mTOR Kinase: <i>In Vitro</i> and <i>In Vivo</i> Characterization

Deborah S. Mortensen, Kimberly E. Fultz, Shuichan Xu, +24

Molecular Cancer Therapeutics

Cancer BiologyMtorc1 ComplexTumor BiologyMolecular PharmacologySignaling Pathway +17

IKK-i signals through IRF3 and NFκB to mediate the production of inflammatory cytokines

Sabita Sankar, Henry Chan, William J. Romanow, +2

Cellular Signalling

InflammationCytokineInflammatory CytokinesSignal TransductionSignaling Pathway +9

Discovery and SAR exploration of a novel series of imidazo[4,5-b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Roy Harris, +7

Bioorganic & Medicinal Chemistry Letters

Sar ExplorationMedicinal ChemistryDrug TargetNovel SeriesBiochemistry +9

Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223

Deborah S. Mortensen, Sophie Perrin-Ninkovic, Graziella Shevlin, +29

Journal of Medicinal Chemistry

Drug TargetKinase InhibitorsPharmacotherapyChemical BiologyPharmaceutical Chemistry +20