Tumor-Associated Macrophages Recruit CCR6+ Regulatory T Cells and Promote the Development of Colorectal Cancer via Enhancing CCL20 Production in Mice

Jinlin Liu, Ning Zhang, Qun Li, +4

PLoS ONE

Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy

Gadi Borkow, Qibin Leng, Ziva Weisman, +4

Journal of Clinical Investigation

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer

Yadong Xie, Yifan Zhao, Lei Shi, +22

Journal of Clinical Investigation

Intestinal InflammationGut Epithelial Tsc1/mtorApoptosisImmunologyPathology +20

Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response

Yan Mei, Xiumei Wang, Ji Zhang, +23

Nature Cancer

Immunotherapy ResponseNeuro-oncologyCancer ImmunosurveillanceImmune-checkpoint MoleculeGlioma +9

Single‐cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

Yan Mei, Weiwei Xiao, Hao Hu, +15

Clinical and Translational Medicine

NLRC5 regulates MHC class I antigen presentation in host defense against intracellular pathogens

Yikun Yao, Yalong Wang, Fuxiang Chen, +6

Cell Research

Host ResponseAutoimmune DiseaseMhc ClassPathogenesisImmunology +8

Reciprocal Regulation between Enterovirus 71 and the NLRP3 Inflammasome

Hongbin Wang, Xiaobo Lei, Xia Xiao, +8

Cell Reports

One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering

Jiankui Zhou, Bin Shen, Jianying Wang, +8

The International Journal of Biochemistry & Cell Biology

Off-target EffectEngineeringGenome SurgeryTransgenic Mouse ModelsImmunology +11

Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice

Zhihua Qi, Gaiyun Li, Hao Hu, +9

Journal of Virology

Viral ReplicationImmunologyHepatitis BMolecular BiologyHbv Cccdna +18

Immune Activation Correlates Better Than HIV Plasma Viral Load with CD4 T-Cell Decline During HIV Infection

Qibin Leng, Gadi Borkow, Ziva Weisman, +3

JAIDS Journal of Acquired Immune Deficiency Syndromes