Toshiharu Shimazaki

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

Shigeyuki Chaki, Ryoko Yoshikawa, Shiho Hirota et al. · Neuropharmacology · 2003 · 250 citations

Antidepressant-like Activity, Psychoactive Drug, Psychiatry +11

Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists

Shigeyuki Chaki, Takeo Funakoshi, Shiho Hirota-Okuno et al. · Journal of Pharmacology and Experimental Therapeutics · 2005 · 132 citations · Full text

An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

Takao Yoshimizu, Toshiharu Shimazaki, Akie Ito et al. · Psychopharmacology · 2006 · 131 citations

Psychoactive Drug, Psychiatry, Behavioral Neuroscience +15

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

Jun-ichi Karasawa, Toshiharu Shimazaki, Naoya Kawashima et al. · Brain Research · 2005 · 130 citations

Psychiatry, Neurophysiology, Medicine +12

Cocaine- and amphetamine-regulated transcript peptide produces anxiety-like behavior in rodents

Shigeyuki Chaki, Naoya Kawashima, Yoshiko Suzuki et al. · European Journal of Pharmacology · 2003 · 97 citations

Substance Abuse, Psychoactive Drug, Behavioral Neuroscience +10