Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer

Hervé Tiriac, Pascal Belleau, Dannielle D. Engle, +67

Cancer Discovery

New insights into the Tyrolean Iceman's origin and phenotype as inferred by whole-genome sequencing

Andreas Keller, Angela Graefen, Markus Ball, +37

Nature Communications

Genome-wide cell-free DNA mutational integration enables ultra-sensitive cancer monitoring

Asaf Zviran, Rafael Schulman, Minita Shah, +39

Nature Medicine

Ultra-sensitive Cancer MonitoringMedicineCancer GenomicsCancer GeneticsMolecular Diagnostics +2

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs

Kevin Hadi, Xiaotong Yao, Julie M. Behr, +49

Cell

BioinformaticsChromatinGraph TheoryTumor HeterogeneityCancer Genome Graphs +11

Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia

Nicole McNeer, John Philip, Heather Geiger, +15

Leukemia

Hematological MalignancyPrimary Chemotherapy ResistanceHealth SciencesPediatric HematologyMedicine +10

Genome-wide somatic variant calling using localized colored de Bruijn graphs

Giuseppe Narzisi, André Corvelo, Kanika Arora, +7

Communications Biology

EngineeringGeneticsReliable DetectionIndel DetectionGenomics +19

PGBD5 promotes site-specific oncogenic mutations in human tumors

Anton G. Henssen, Richard P. Koche, Jiali Zhuang, +27

Nature Genetics

Tumor BiologyOncogenic AgentCancer GenomicsCancer GeneticsSite-specific Oncogenic Mutations +3

Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

Adam J. Widman, Minita Shah, Amanda Frydendahl, +58

Nature Medicine

EngineeringCancer DetectionMedicineTumor BurdenBiomedical Imaging +9

Deep whole-genome sequencing of 3 cancer cell lines on 2 sequencing platforms

Kanika Arora, Minita Shah, Molly Johnson, +9

Scientific Reports

A recurrent novel <i>MGA–NUTM1</i> fusion identifies a new subtype of high-grade spindle cell sarcoma

Daniel Diolaiti, Filemon S. Dela Cruz, Gunes Gundem, +17

Molecular Case Studies