Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

Mika Hayakawa, Kazuki Hattori, Satoru Sugiyama, +1

Biochemical and Biophysical Research Communications

CardiomyopathyHeart FailureAgingMitochondrial FunctionLongevity +10

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

Mika Hayakawa, Keizo Torii, Satoru Sugiyama, +2

Biochemical and Biophysical Research Communications

BiologyDnaMitochondrial FunctionMitochondrial DynamicGenetics +6

Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine

Mika Hayakawa, Takuo Ogawa, Satoru Sugiyama, +2

Biochemical and Biophysical Research Communications

Massive ConversionDnaMitochondrial BiogenesisMitochondrial FunctionBiochemistry +4

Adverse effects of anti-tumor drug, cisplatin, on rat kidney mitochondria: Disturbances in glutathione peroxidase activity

Satoru Sugiyama, Mika Hayakawa, Tomoko S. Kato, +3

Biochemical and Biophysical Research Communications

Anti-tumor DrugMitochondrial FunctionMedicineLipid PeroxidationAdverse Effects +8

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

Satoru Sugiyama, Kazuki Hattori, Mika Hayakawa, +1

Biochemical and Biophysical Research Communications

Heart FailureAgingMitochondrial FunctionLongevityGenetics +7

Age-associated damage in mitochondrial DNA in human hearts

Mika Hayakawa, Satoru Sugiyama, Kazuki Hattori, +2

Molecular and Cellular Biochemistry

Heart FailureDna DamageAgingMitochondrial FunctionLongevity +5

Biosynthesis of leukotoxin, 9, 10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia

Takayuki Ozawa, Mika Hayakawa, Tadanobu Takamura, +5

Biochemical and Biophysical Research Communications

InflammationRespiratory ToxicologyMedicineImmunology10-Epoxy-12 Octadecenoate +7

Existence of Leukotoxin 9,10-Epoxy-12-Octadecenoate in Lung Lavages from Rats Breathing Pure Oxygen and from Patients with the Adult Respiratory Distress Syndrome

Takayuki Ozawa, Satoru Sugiyama, Mika Hayakawa, +4

American Review of Respiratory Disease

AsthmaAcute Lung InjuryLeukotoxin 9,10-Epoxy-12-octadecenoateLung InflammationEdematous Lung Injury +16

Neutrophils biosynthesize leukotoxin, 9, 10-epoxy-12-octadecenoate

Mika Hayakawa, Satoru Sugiyama, Tadanobu Takamura, +6

Biochemical and Biophysical Research Communications

InflammationGranulocyteImmunologyPhagocyteMedicine +2

Leukotoxin, a linoleate epoxide: Its implication in the late death of patients with extensive burns

Kazuhiro Kosaka, Kohji SUZUKI, Mika Hayakawa, +2

Molecular and Cellular Biochemistry

InflammationLinoleate EpoxideAllergyExtensive BurnsPathology +8