Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts

Mika Hayakawa, Kazuki Hattori, Satoru Sugiyama, +1

Biochemical and Biophysical Research Communications

CardiomyopathyHeart FailureAgingMitochondrial FunctionLongevity +10

Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia

Kazuki Hattori, Masashi Tanaka, Satoru Sugiyama, +7

American Heart Journal

CardiomyopathyAgingMitochondrial FunctionCardiovascular DiseaseGenetics +9

Age-associated accumulation of 8-hydroxydeoxyguanosine in mitochondrial DNA of human diaphragm

Mika Hayakawa, Keizo Torii, Satoru Sugiyama, +2

Biochemical and Biophysical Research Communications

BiologyDnaMitochondrial FunctionMitochondrial DynamicGenetics +6

Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy

Takayuki Ozawa, Masashi Tanaka, Satoru Sugiyama, +11

Biochemical and Biophysical Research Communications

Cardiac MuscleCardiomyopathyHeart FailureMitochondrial FunctionGenetics +7

Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine

Mika Hayakawa, Takuo Ogawa, Satoru Sugiyama, +2

Biochemical and Biophysical Research Communications

Massive ConversionDnaMitochondrial BiogenesisMitochondrial FunctionBiochemistry +4

Point mutations in mitochondrial DNA in patients with hypertrophic cardiomyopathy

Toshihiro Obayashi, Kazuki Hattori, Satoru Sugiyama, +11

American Heart Journal

CardiomyopathyMitochondrial FunctionNatural SciencesGeneticsDna Replication +6

Adverse effects of anti-tumor drug, cisplatin, on rat kidney mitochondria: Disturbances in glutathione peroxidase activity

Satoru Sugiyama, Mika Hayakawa, Tomoko S. Kato, +3

Biochemical and Biophysical Research Communications

Anti-tumor DrugMitochondrial FunctionMedicineLipid PeroxidationAdverse Effects +8

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

Satoru Sugiyama, Kazuki Hattori, Mika Hayakawa, +1

Biochemical and Biophysical Research Communications

Heart FailureAgingMitochondrial FunctionLongevityGenetics +7

Age-associated damage in mitochondrial DNA in human hearts

Mika Hayakawa, Satoru Sugiyama, Kazuki Hattori, +2

Molecular and Cellular Biochemistry

Heart FailureDna DamageAgingMitochondrial FunctionLongevity +5

Patients with idiopathic cardiomyopathy belong to the same mitochondrial DNA gene family of Parkinson's disease and mitochondrial encephalomyopathy

Takayuki Ozawa, Masashi Tanaka, Satoru Sugiyama, +9

Biochemical and Biophysical Research Communications

Mitochondrial MyopathyCardiomyopathyMitochondrial BiogenesisMitochondrial FunctionGenetics +8