CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities

Kyuho Han, Sarah E. Pierce, Amy Li, +22

Nature

Crispr ScreensGene EditingGenome EditingMedicineCell Biology +2

Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis

Roarke A. Kamber, Yoko Nishiga, Bhek Morton, +15

Nature

Tumor BiologyInter-cellular Crispr ScreensCancer Cell BiologyGene EditingGenome Editing +4

High-Throughput Discovery and Characterization of Human Transcriptional Effectors

Josh Tycko, Nicole DelRosso, Gaelen T. Hess, +12

Cell

High-throughput DiscoveryTranscriptional RegulationFunctional GenomicsGeneticsTranscriptomics Technology +6

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

Josh Tycko, Michael Wainberg, Georgi K. Marinov, +18

Nature Communications

A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions

Rockie Chong, Kimberly D. Insigne, David Yao, +7

Molecular Cell

BioinformaticsGenetic DisorderGeneticsExon Recognition RevealsMolecular Biology +9

Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment

Xiang-Ling Meng, David Yao, Kent Imaizumi, +9

Nature

Nitrosative and oxidative stress links dysfunctional ubiquitination to Parkinson's disease

Zhi‐Chun Gu, Tomohiro Nakamura, David Yao, +2

Cell Death and Differentiation

Reductive StressReactive Nitrogen SpeciePhysiologyNeuroprotectionNeurology +5

An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens

Robert Coukos, David Yao, Mateo I. Sánchez, +7

eLife

EngineeringProtein ColocalizationMolecular BiologyGene Perturbation ScreensTranscriptional Regulation +22

Death-seq identifies regulators of cell death and senolytic therapies

Alex Colville, Jie‐Yu Liu, Cristina Rodríguez-Mateo, +16

Cell Metabolism

ApoptosisCell DeathImmune Checkpoint InhibitorImmunotherapyMedicine +2

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

David W. Morgens, Charlene Chan, Andrew J Kane, +17

eLife

Retrograde TransportMolecular BiologyCrisprSecretory PathwayCell Signaling +17