Development of an intein-mediated split–Cas9 system for gene therapy

Dong‐Jiunn Jeffery Truong, Karin Kühner, Ralf Kühn, +4

Nucleic Acids Research

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Caroline Fecher, Laura Trovò, Stephan A. Müller, +15

Nature Neuroscience

Neurodegenerative DiseasesMolecular NeuroscienceMitochondrial FunctionCell-type-specific ProfilingNeurochemical Biomarkers +6

Striatal Adenosine A2A and Cannabinoid CB1 Receptors Form Functional Heteromeric Complexes that Mediate the Motor Effects of Cannabinoids

Paulina Carriba, Oskar Ortiz, Kshitij A. Patkar, +13

Neuropsychopharmacology

Cannabis UseMotor EffectsNeurophysiologyMedicineFunctional Selectivity +10

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

Benedikt Wefers, Mélanie Meyer, Oskar Ortiz, +4

Proceedings of the National Academy of Sciences

EngineeringTransgenic Mouse ModelsGeneticsGene DeliveryEmbryology +19

Associative Learning and CA3–CA1 Synaptic Plasticity Are Impaired in D₁R Null,<i>Drd1a</i>^−/−Mice and in Hippocampal siRNA Silenced<i>Drd1a</i>Mice

Oskar Ortiz, José M. Delgado‐García, Isabel Espadas, +5

Journal of Neuroscience

Associative LearningSynaptic TransmissionNeurotransmissionStructural PlasticitySynaptic Signaling +16

Highly Efficient Targeted Mutagenesis in Mice Using TALENs

Sudeepta Kumar Panda, Benedikt Wefers, Oskar Ortiz, +4

Genetics

Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA

Benedikt Wefers, Sudeepta Kumar Panda, Oskar Ortiz, +5

Nature Protocols

Developmental BiologyTalen MrnaTargeted Mouse MutantsGeneticsEmbryo Microinjection +9

L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: Insights into regulation and function

Isabel Espadas, Sanja Darmopil, Eva Vergaño‐Vera, +5

Neurobiology of Disease

MedicineTh-immunoreactive Striatal NeuronsL-dopa-induced IncreaseNeuropharmacologyNeuroscience +5

Modeling disease mutations by gene targeting in one-cell mouse embryos

Mélanie Meyer, Oskar Ortiz, Martin Hrabě de Angelis, +2

Proceedings of the National Academy of Sciences

Transgenic Mouse ModelsGeneticsDisease Gene IdentificationSynthetic OligodesoxynucleotidesOne-cell Embryos +14

Metabolic interactions between glutamatergic and dopaminergic neurotransmitter systems are mediated through D₁ dopamine receptors

Tiago B. Rodrigues, Noelia Granado, Oskar Ortiz, +2

Journal of Neuroscience Research