Joachim W. Engels

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

Jesper B. Bramsen, Maria Bach Laursen, A. Nielsen et al. · Nucleic Acids Research · 2009 · 349 citations · Full text

Synthesis, structure, and reactivity of adenosine cyclic 3',5'-phosphate-benzyltriesters

Joachim W. Engels, Ernst Juergen Schlaeger · Journal of Medicinal Chemistry · 1977 · 250 citations

Organic Chemistry, Chemistry, Chemical Biology +16

A PELDOR-Based Nanometer Distance Ruler for Oligonucleotides

Olav Schiemann, Nelly Piton, Yuguang Mu et al. · Journal of the American Chemical Society · 2004 · 205 citations

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

Jesper B. Bramsen, Malgorzata Maria Pakula, Thomas B. Hansen et al. · Nucleic Acids Research · 2010 · 191 citations · Full text

Long‐Range Distance Measurements on Nucleic Acids in Cells by Pulsed EPR Spectroscopy

Ivan Krstić, Robert Hänsel, Olga Romainczyk et al. · Angewandte Chemie International Edition · 2011 · 183 citations

Hairpin Rna, Dna Analysis, Molecular Biology +21