Discovery of a Novel Binding Trench in HIV Integrase

Julie R. Schames, Richard H. Henchman, Jay S. Siegel, +3

Journal of Medicinal Chemistry

Drug TargetImmunologyMolecular BiologyAntiviral DrugHiv-1 Therapeutics +15

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ann E. Eakin, Oluyinka Green, Neil J. Hales, +22

Antimicrobial Agents and Chemotherapy

Essential EnzymeLead IdentificationAntimicrobial ChemotherapyChemical BiologyPharmaceutical Chemistry +16

Thalassiolins A–C: new marine-derived inhibitors of HIV cDNA integrase

David Rowley, Mark Hansen, Denise Rhodes, +5

Bioorganic & Medicinal Chemistry

Hiv Cdna IntegraseMedicineAntiviral Drug DevelopmentHivPharmacology +2

Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

John W. Cuozzo, Matthew Clark, Anthony D. Keefe, +11

Journal of Medicinal Chemistry

The Importance of Coulombic End Effects: Experimental Characterization of the Effects of Oligonucleotide Flanking Charges on the Strength and Salt Dependence of Oligocation (L8+) Binding to Single-Stranded DNA Oligomers

Wentao Zhang, Haihong Ni, W. Michael, +3

Biophysical Journal

Dna NanotechnologyBiochemistryProtein FoldingNatural SciencesSalt Dependence +6

Quantifying the Thermodynamic Consequences of Cation (M²⁺, M⁺) Accumulation and Anion (X^-) Exclusion in Mixed Salt Solutions of Polyanionic DNA Using Monte Carlo and Poisson−Boltzmann Calculations of Ion−Polyion Preferential Interaction Coefficients

Haihong Ni, Charles Anderson, M. Thomas Record

The Journal of Physical Chemistry B

EngineeringMolecular BiologyComputational ChemistryChemistryComputational Biophysics +16

A novel drug repurposing approach for non-small cell lung cancer using deep learning

Bingrui Li, Chan Dai, Lijun Wang, +4

PLoS ONE

Drug TargetEngineeringMedicinal ChemistryRadiation OncologyNovel Drug +18

HIV-1 Integrase Inhibitor Interactions at the Active Site:  Prediction of Binding Modes Unaffected by Crystal Packing

Christoph Sotriffer, Haihong Ni, J. Andrew McCammon

Journal of the American Chemical Society

Drug TargetAltmetric Attention ScoreMolecular BiologyAntiviral DrugChemical Biology +21

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Boudewijn L. M. de Jonge, Grant K. Walkup, Sushmita D. Lahiri, +19

Antimicrobial Agents and Chemotherapy

Bioorganic ChemistryAntibiotic AdjuvantValidate PpatAntimicrobial ChemotherapyChemical Biology +20

Growth of large-size crystal of PbWO4 by vertical Bridgman method with multi-crucibles

Peizhi Yang, Jingying Liao, Shen Bingfu, +3

Journal of Crystal Growth

Materials EngineeringMaterials ScienceCrystal StructureEngineeringCrystal Material +8